Gene description for NOMO3
Gene name NODAL modulator 3
Gene symbol NOMO3
Other names/aliases Nomo
Species Homo sapiens
 Database cross references - NOMO3
ExoCarta ExoCarta_408050
Vesiclepedia VP_408050
Entrez Gene 408050
HGNC 25242
MIM 609159
UniProt P69849  
 NOMO3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for NOMO3
Molecular Function
    protein binding GO:0005515 IPI
    carbohydrate binding GO:0030246 IEA
    ribosome binding GO:0043022 IDA
Biological Process
    determination of left/right asymmetry in lateral mesoderm GO:0003140 ISS
    multi-pass transmembrane protein insertion into ER membrane GO:0160063 IDA
    negative regulation of nodal signaling pathway GO:1900108 ISS
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IBA
    multi-pass translocon complex GO:0160064 IDA
 Experiment description of studies that identified NOMO3 in exosomes
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for NOMO3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NOMO1 23420
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LIG4 3981
Two-hybrid Homo sapiens
3 C9orf72  
Affinity Capture-MS Homo sapiens
4 RBM42  
Affinity Capture-MS Homo sapiens
5 UBQLN4 56893
Two-hybrid Homo sapiens
6 RBM8A 9939
Affinity Capture-MS Homo sapiens
7 PLD4  
Affinity Capture-MS Homo sapiens
8 TPT1 7178
Affinity Capture-MS Homo sapiens
9 TMEM25  
Affinity Capture-MS Homo sapiens
10 GGH 8836
Affinity Capture-MS Homo sapiens
11 SRP9 6726
Affinity Capture-MS Homo sapiens
12 CMKLR1 1240
Affinity Capture-MS Homo sapiens
13 RYK 6259
Affinity Capture-MS Homo sapiens
14 TRIM65 201292
Affinity Capture-MS Homo sapiens
15 NR3C1 2908
Proximity Label-MS Homo sapiens
16 CBLN4  
Affinity Capture-MS Homo sapiens
17 SRP72 6731
Affinity Capture-MS Homo sapiens
18 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
19 RPL4 6124
Affinity Capture-MS Homo sapiens
20 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 G3BP2 9908
Affinity Capture-MS Homo sapiens
22 DRG1 4733
Affinity Capture-MS Homo sapiens
23 MAP3K7  
Affinity Capture-MS Homo sapiens
24 SFTPC  
Affinity Capture-MS Homo sapiens
25 RPL5 6125
Affinity Capture-MS Homo sapiens
26 PLD3 23646
Affinity Capture-MS Homo sapiens
27 BRICD5  
Affinity Capture-MS Homo sapiens
28 PSPC1 55269
Affinity Capture-MS Homo sapiens
29 SDF2L1 23753
Affinity Capture-MS Homo sapiens
30 SRP19 6728
Affinity Capture-MS Homo sapiens
31 FBXO2 26232
Affinity Capture-MS Homo sapiens
32 TMCO1 54499
Affinity Capture-MS Homo sapiens
33 TAB2  
Affinity Capture-MS Homo sapiens
34 NCLN 56926
Affinity Capture-MS Homo sapiens
35 METAP2 10988
Affinity Capture-MS Homo sapiens
36 TAB3 257397
Affinity Capture-MS Homo sapiens
37 GNB2L1 10399
Affinity Capture-MS Homo sapiens
38 TPCN2  
Affinity Capture-MS Homo sapiens
39 TMEM147 10430
Affinity Capture-MS Homo sapiens
40 ST14 6768
Affinity Capture-MS Homo sapiens
41 RPS16 6217
Affinity Capture-MS Homo sapiens
42 GET4 51608
Affinity Capture-MS Homo sapiens
43 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TMPRSS13  
Affinity Capture-MS Homo sapiens
45 HMGB2 3148
Affinity Capture-MS Homo sapiens
46 CCDC47 57003
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NOMO3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here