Gene description for GALNT3
Gene name polypeptide N-acetylgalactosaminyltransferase 3
Gene symbol GALNT3
Other names/aliases GalNAc-T3
HFTC
HHS
Species Homo sapiens
 Database cross references - GALNT3
ExoCarta ExoCarta_2591
Entrez Gene 2591
HGNC 4125
MIM 601756
UniProt Q14435  
 GALNT3 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for GALNT3
Molecular Function
    carbohydrate binding GO:0030246 IEA
    calcium ion binding GO:0005509 IDA
    polypeptide N-acetylgalactosaminyltransferase activity GO:0004653 IDA
    protein binding GO:0005515 IPI
    manganese ion binding GO:0030145 IDA
Biological Process
    O-glycan processing GO:0016266 TAS
    post-translational protein modification GO:0043687 TAS
    carbohydrate metabolic process GO:0005975 NAS
    cellular protein metabolic process GO:0044267 TAS
    protein O-linked glycosylation via serine GO:0018242 IDA
    protein O-linked glycosylation GO:0006493 TAS
    protein O-linked glycosylation via threonine GO:0018243 IDA
Subcellular Localization
    Golgi cisterna membrane GO:0032580 IEA
    Golgi membrane GO:0000139 TAS
    extracellular exosome GO:0070062 IDA
    Golgi apparatus GO:0005794 IDA
    membrane GO:0016020 TAS
    integral component of membrane GO:0016021 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified GALNT3 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GALNT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GALNT3 is involved
PathwayEvidenceSource
O-linked glycosylation of mucins TAS Reactome





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