Gene description for AP5Z1
Gene name adaptor-related protein complex 5, zeta 1 subunit
Gene symbol AP5Z1
Other names/aliases KIAA0415
SPG48
zeta
Species Homo sapiens
 Database cross references - AP5Z1
ExoCarta ExoCarta_9907
Vesiclepedia VP_9907
Entrez Gene 9907
HGNC 22197
MIM 613653
UniProt O43299  
 AP5Z1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for AP5Z1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    autophagosome assembly GO:0000045 IEA
    double-strand break repair via homologous recombination GO:0000724 IMP
    intracellular protein transport GO:0006886 IEA
    Golgi organization GO:0007030 IEA
    lysosome organization GO:0007040 IEA
    gene expression GO:0010467 IEA
    vesicle-mediated transport GO:0016192 NAS
    endosomal transport GO:0016197 IMP
    late endosome to Golgi transport GO:0034499 IEA
    axon development GO:0061564 IEA
    lysosomal protein catabolic process GO:1905146 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    lysosome GO:0005764 IEA
    late endosome GO:0005770 NAS
    nuclear speck GO:0016607 IDA
    AP-type membrane coat adaptor complex GO:0030119 NAS
    AP-5 adaptor complex GO:0044599 NAS
 Experiment description of studies that identified AP5Z1 in exosomes
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AP5Z1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STUB1 10273
Affinity Capture-MS Homo sapiens
2 BAG3 9531
Affinity Capture-MS Homo sapiens
3 TUSC2  
Affinity Capture-MS Homo sapiens
4 PRKAA1 5562
Affinity Capture-MS Homo sapiens
5 CXCR4 7852
Affinity Capture-MS Homo sapiens
6 HSPA8 3312
Affinity Capture-MS Homo sapiens
7 FPR1  
Affinity Capture-MS Homo sapiens
8 BAG2 9532
Affinity Capture-MS Homo sapiens
9 BAG5 9529
Affinity Capture-MS Homo sapiens
10 NPTN 27020
Affinity Capture-MS Homo sapiens
11 AP5S1  
Affinity Capture-MS Homo sapiens
12 MEX3A  
Affinity Capture-RNA Homo sapiens
13 MDFI  
Two-hybrid Homo sapiens
14 C9orf78 51759
Affinity Capture-MS Homo sapiens
15 IRF2 3660
Affinity Capture-MS Homo sapiens
16 FOXK1 221937
Affinity Capture-MS Homo sapiens
17 DDX58 23586
Affinity Capture-RNA Homo sapiens
18 SPG11 80208
Affinity Capture-MS Homo sapiens
19 BAG1 573
Affinity Capture-MS Homo sapiens
20 HSPA2 3306
Affinity Capture-MS Homo sapiens
21 GPR182  
Affinity Capture-MS Homo sapiens
22 HSPA4 3308
Affinity Capture-MS Homo sapiens
23 SERBP1 26135
Affinity Capture-MS Homo sapiens
24 PTH2R  
Affinity Capture-MS Homo sapiens
25 NUP93 9688
Two-hybrid Homo sapiens
26 RIN3  
Affinity Capture-MS Homo sapiens
27 PRKAB1 5564
Affinity Capture-MS Homo sapiens
28 LYPD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 HSPA1B 3304
Affinity Capture-MS Homo sapiens
30 SAYSD1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which AP5Z1 is involved
No pathways found





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