Gene description for PLCE1
Gene name	phospholipase C, epsilon 1
Gene symbol	PLCE1
Other names/aliases	NPHS3 PLCE PPLC
Species	Homo sapiens
Database cross references - PLCE1
ExoCarta	ExoCarta_51196
Entrez Gene	51196
HGNC	17175
MIM	608414
UniProt	Q9P212
PLCE1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells	20124223

Gene ontology annotations for PLCE1

Molecular Function     phospholipase C activity GO:0004629 IDA     receptor signaling protein activity GO:0005057 TAS     enzyme binding GO:0019899 IPI     protein binding GO:0005515 IPI     phosphatidylinositol phospholipase C activity GO:0004435 IDA     guanyl-nucleotide exchange factor activity GO:0005085 TAS     Ras GTPase binding GO:0017016 TAS Biological Process     Ras protein signal transduction GO:0007265 TAS     activation of MAPK activity GO:0000187 IDA     cytoskeleton organization GO:0007010 NAS     calcium-mediated signaling GO:0019722 TAS     small molecule metabolic process GO:0044281 TAS     inositol phosphate metabolic process GO:0043647 TAS     phospholipid metabolic process GO:0006644 IC     cell proliferation GO:0008283 NAS     heart development GO:0007507 TAS     lipid catabolic process GO:0016042 IEA     regulation of smooth muscle contraction GO:0006940 TAS     diacylglycerol biosynthetic process GO:0006651 TAS     epidermal growth factor receptor signaling pathway GO:0007173 NAS     positive regulation of GTPase activity GO:0043547 TAS     glomerulus development GO:0032835 IMP     inositol phosphate-mediated signaling GO:0048016 TAS     protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205 NAS     regulation of cell growth GO:0001558 TAS     regulation of protein kinase activity GO:0045859 IDA     regulation of G-protein coupled receptor protein signaling pathway GO:0008277 IDA     positive regulation of cytosolic calcium ion concentration GO:0007204 TAS     regulation of Ras protein signal transduction GO:0046578 IDA     phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 IDA Subcellular Localization     cytoplasm GO:0005737 IDA     plasma membrane GO:0005886 TAS     cytosol GO:0005829 IDA     Golgi membrane GO:0000139 IEA