Gene description for GLTP
Gene name glycolipid transfer protein
Gene symbol GLTP
Other names/aliases -
Species Homo sapiens
 Database cross references - GLTP
ExoCarta ExoCarta_51228
Vesiclepedia VP_51228
Entrez Gene 51228
HGNC 24867
MIM 608949
UniProt Q9NZD2  
 GLTP identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for GLTP
Molecular Function
    protein binding GO:0005515 IPI
    glycolipid binding GO:0051861 IDA
    glycolipid transporter activity GO:0017089 IDA
    lipid binding GO:0008289 IDA
Biological Process
    glycolipid transport GO:0046836 IDA
    sphingolipid metabolic process GO:0006665 TAS
    glycosphingolipid metabolic process GO:0006687 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    membrane GO:0016020 IC
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified GLTP in exosomes
1
Experiment ID 235
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for GLTP
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GLTP is involved
PathwayEvidenceSource
Glycosphingolipid metabolism TAS Reactome





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