Gene description for GLTP
Gene name glycolipid transfer protein
Gene symbol GLTP
Other names/aliases -
Species Homo sapiens
 Database cross references - GLTP
ExoCarta ExoCarta_51228
Vesiclepedia VP_51228
Entrez Gene 51228
HGNC 24867
MIM 608949
UniProt Q9NZD2  
 GLTP identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for GLTP
Molecular Function
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IDA
    glycolipid transfer activity GO:0017089 TAS
    identical protein binding GO:0042802 IPI
    glycolipid binding GO:0051861 IDA
    lipid transfer activity GO:0120013 IDA
    ceramide 1-phosphate binding GO:1902387 IBA
    ceramide 1-phosphate transfer activity GO:1902388 IBA
Biological Process
    ceramide transport GO:0035627 IBA
    ceramide transport GO:0035627 TAS
    response to immobilization stress GO:0035902 IEA
    glycolipid transport GO:0046836 IEA
    intermembrane lipid transfer GO:0120009 IBA
    intermembrane lipid transfer GO:0120009 IDA
    ceramide 1-phosphate transport GO:1902389 IEA
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified GLTP in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for GLTP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FNDC5  
Affinity Capture-MS Homo sapiens
2 SHKBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 STARD7 56910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 UBE2T  
Cross-Linking-MS (XL-MS) Homo sapiens
6 MBNL1 4154
Affinity Capture-MS Homo sapiens
7 HCN1  
Affinity Capture-MS Homo sapiens
8 ASPSCR1 79058
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ETFB 2109
Co-fractionation Homo sapiens
10 CCR1  
Affinity Capture-MS Homo sapiens
11 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
12 STX17 55014
Affinity Capture-MS Homo sapiens
13 CEBPA  
Protein-peptide Homo sapiens
14 CMTM5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 AMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 C21orf33  
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which GLTP is involved
PathwayEvidenceSource
Glycosphingolipid transport TAS Reactome
Transport of small molecules TAS Reactome





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