Gene description for Hist2h2ab
Gene name histone cluster 2, H2ab
Gene symbol Hist2h2ab
Other names/aliases EG621893
H2a-613a
Species Mus musculus
 Database cross references - Hist2h2ab
ExoCarta ExoCarta_621893
Entrez Gene 621893
UniProt Q64522  
 Hist2h2ab identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Hist2h2ab
Molecular Function
    protein heterodimerization activity GO:0046982 IEA
    DNA binding GO:0003677 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleosome GO:0000786 IEA
    chromosome GO:0005694 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Hist2h2ab in exosomes
1
Experiment ID 264
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hist2h2ab
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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