Gene description for COX2
Gene name cytochrome c oxidase II, mitochondrial
Gene symbol COX2
Other names/aliases -
Species Mus musculus
 Database cross references - COX2
ExoCarta ExoCarta_17709
Vesiclepedia VP_17709
Entrez Gene 17709
UniProt P00405  
 COX2 identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for COX2
Molecular Function
    cytochrome-c oxidase activity GO:0004129 IBA
    cytochrome-c oxidase activity GO:0004129 ISO
    cytochrome-c oxidase activity GO:0004129 ISS
    copper ion binding GO:0005507 IEA
Biological Process
    response to hypoxia GO:0001666 IEA
    lactation GO:0007595 IEA
    electron transport chain GO:0022900 IEA
    ATP synthesis coupled electron transport GO:0042773 IBA
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 ISO
    mitochondrial membrane GO:0031966 ISO
    respiratory chain complex IV GO:0045277 IDA
    respiratory chain complex IV GO:0045277 ISO
    respiratory chain complex IV GO:0045277 ISS
 Experiment description of studies that identified COX2 in sEVs
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for COX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Mapt  
Affinity Capture-MS Mus musculus
3 Eed  
Affinity Capture-MS Mus musculus
4 SNCA 6622
Affinity Capture-MS Homo sapiens
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