Gene description for ARHGAP15
Gene name Rho GTPase activating protein 15
Gene symbol ARHGAP15
Other names/aliases BM046
Species Homo sapiens
 Database cross references - ARHGAP15
ExoCarta ExoCarta_55843
Vesiclepedia VP_55843
Entrez Gene 55843
HGNC 21030
MIM 610578
UniProt Q53QZ3  
 ARHGAP15 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ARHGAP15
Molecular Function
    GTPase activator activity GO:0005096 IBA
    GTPase activator activity GO:0005096 IDA
    GTPase activator activity GO:0005096 TAS
    protein binding GO:0005515 IPI
Biological Process
    small GTPase-mediated signal transduction GO:0007264 IBA
    regulation of cell shape GO:0008360 IDA
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified ARHGAP15 in sEVs
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARHGAP15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 ATG16L1 55054
Affinity Capture-MS Homo sapiens
3 EDC4 23644
Affinity Capture-MS Homo sapiens
4 HACD3 51495
Affinity Capture-MS Homo sapiens
5 SNCA 6622
Reconstituted Complex Homo sapiens
6 SCD 6319
Affinity Capture-MS Homo sapiens
7 BCAP31 10134
Affinity Capture-MS Homo sapiens
8 RAC1 5879
Reconstituted Complex Homo sapiens
9 KDM1A 23028
Two-hybrid Homo sapiens
10 PGRMC1 10857
Affinity Capture-MS Homo sapiens
11 CYB5A 1528
Affinity Capture-MS Homo sapiens
12 ESYT1 23344
Affinity Capture-MS Homo sapiens
13 CEBPA  
Protein-peptide Homo sapiens
14 PRNP 5621
Reconstituted Complex Homo sapiens
15 DHPS 1725
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MICAL2 9645
Affinity Capture-MS Homo sapiens
17 BCAP29 55973
Affinity Capture-MS Homo sapiens
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