Gene description for Tomm22
Gene name translocase of outer mitochondrial membrane 22 homolog (yeast)
Gene symbol Tomm22
Other names/aliases 2310047D01
Tom22
Species Mus musculus
 Database cross references - Tomm22
ExoCarta ExoCarta_223696
Vesiclepedia VP_223696
Entrez Gene 223696
UniProt Q9CPQ3  
 Tomm22 identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Tomm22
Molecular Function
    protein binding GO:0005515 IPI
    protein transmembrane transporter activity GO:0008320 ISO
    mitochondrion targeting sequence binding GO:0030943 IEA
    mitochondrion targeting sequence binding GO:0030943 ISO
Biological Process
    protein targeting to mitochondrion GO:0006626 ISO
    protein targeting to mitochondrion GO:0006626 ISS
    positive regulation of apoptotic process GO:0043065 ISO
    protein insertion into mitochondrial outer membrane GO:0045040 IEA
    protein insertion into mitochondrial outer membrane GO:0045040 ISO
    protein insertion into mitochondrial membrane GO:0051204 ISO
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 ISO
    mitochondrial outer membrane translocase complex GO:0005742 IEA
    mitochondrial outer membrane translocase complex GO:0005742 ISO
    mitochondrial inner membrane GO:0005743 HDA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Tomm22 in sEVs
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tomm22
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fitm2  
Negative Genetic Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
3 SNCA 6622
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Tomm22 is involved
PathwayEvidenceSource
Autophagy IEA Reactome
Macroautophagy IEA Reactome
Mitophagy IEA Reactome
PINK1-PRKN Mediated Mitophagy IEA Reactome
Selective autophagy IEA Reactome





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