Gene description for CDC42EP3
Gene name CDC42 effector protein (Rho GTPase binding) 3
Gene symbol CDC42EP3
Other names/aliases BORG2
CEP3
UB1
Species Homo sapiens
 Database cross references - CDC42EP3
ExoCarta ExoCarta_10602
Vesiclepedia VP_10602
Entrez Gene 10602
HGNC 16943
MIM 606133
UniProt Q9UKI2  
 CDC42EP3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CDC42EP3
Molecular Function
    protein binding GO:0005515 IPI
    cytoskeletal regulatory protein binding GO:0005519 TAS
    small GTPase binding GO:0031267 IBA
Biological Process
    signal transduction GO:0007165 TAS
    Rho protein signal transduction GO:0007266 IBA
    regulation of cell shape GO:0008360 IBA
    positive regulation of actin filament polymerization GO:0030838 IBA
    positive regulation of pseudopodium assembly GO:0031274 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IBA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    endomembrane system GO:0012505 IEA
    actin cytoskeleton GO:0015629 IDA
 Experiment description of studies that identified CDC42EP3 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CDC42EP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UMPS 7372
Two-hybrid Homo sapiens
2 CDC42 998
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
3 SNCA 6622
Reconstituted Complex Homo sapiens
4 SEPT7 989
Reconstituted Complex Homo sapiens
5 CDC42EP3 10602
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
6 MON1B 22879
Affinity Capture-MS Homo sapiens
7 RHOQ 23433
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
8 SRPK1 6732
Biochemical Activity Homo sapiens
9 COPE 11316
Two-hybrid Homo sapiens
10 SEPT6 23157
Reconstituted Complex Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here