Gene description for Vapa
Gene name vesicle-associated membrane protein, associated protein A
Gene symbol Vapa
Other names/aliases 33kDa
VAP33
Species Mus musculus
 Database cross references - Vapa
ExoCarta ExoCarta_30960
Vesiclepedia VP_30960
Entrez Gene 30960
UniProt Q9WV55  
 Vapa identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Vapa
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IEA
    microtubule binding GO:0008017 ISO
    protein domain specific binding GO:0019904 ISO
    FFAT motif binding GO:0033149 IEA
    FFAT motif binding GO:0033149 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    protein-membrane adaptor activity GO:0043495 IBA
    protein-containing complex binding GO:0044877 ISO
    protein heterodimerization activity GO:0046982 IEA
    protein heterodimerization activity GO:0046982 ISO
Biological Process
    sphingomyelin biosynthetic process GO:0006686 ISO
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 ISO
    phospholipid transport GO:0015914 ISO
    sterol transport GO:0015918 ISO
    viral release from host cell GO:0019076 IEA
    viral release from host cell GO:0019076 ISO
    cholesterol transport GO:0030301 IEA
    cholesterol transport GO:0030301 ISO
    neuron projection development GO:0031175 IBA
    neuron projection development GO:0031175 ISO
    neuron projection development GO:0031175 ISS
    ceramide transport GO:0035627 ISO
    negative regulation by host of viral genome replication GO:0044828 IEA
    negative regulation by host of viral genome replication GO:0044828 ISO
    positive regulation by host of viral genome replication GO:0044829 IEA
    positive regulation by host of viral genome replication GO:0044829 ISO
    endoplasmic reticulum-plasma membrane tethering GO:0061817 IEA
    endoplasmic reticulum-plasma membrane tethering GO:0061817 ISO
    protein localization to endoplasmic reticulum GO:0070972 ISO
    protein localization to endoplasmic reticulum GO:0070972 ISS
    COPII-coated vesicle budding GO:0090114 IEA
    COPII-coated vesicle budding GO:0090114 ISO
Subcellular Localization
    Golgi membrane GO:0000139 ISO
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 ISO
    endoplasmic reticulum membrane GO:0005789 ISS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    bicellular tight junction GO:0005923 IEA
    bicellular tight junction GO:0005923 ISO
    microtubule cytoskeleton GO:0015630 IDA
    membrane GO:0016020 ISO
    nuclear membrane GO:0031965 IEA
    nuclear membrane GO:0031965 ISO
    vesicle GO:0031982 IEA
    vesicle GO:0031982 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Vapa in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Vapa
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nphs2  
Affinity Capture-MS Mus musculus
2 Mettl21e  
Affinity Capture-MS Mus musculus
3 Tmem173  
Proximity Label-MS Mus musculus
4 SNCA 6622
Affinity Capture-MS Homo sapiens
5 Atxn1  
Affinity Capture-MS Mus musculus
6 Faf1  
Co-fractionation Mus musculus
7 Eed  
Affinity Capture-MS Mus musculus
8 Oprm1  
Affinity Capture-Western Mus musculus
9 Olfm1  
Affinity Capture-MS Mus musculus
10 Osbp 76303
Co-fractionation Mus musculus
11 Atg16l1  
Affinity Capture-MS Mus musculus
12 Ttc1  
Co-fractionation Mus musculus
13 Rmdn3  
Co-fractionation Mus musculus
14 Fancd2  
Affinity Capture-MS Mus musculus
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