Gene description for Lyn
Gene name	LYN proto-oncogene, Src family tyrosine kinase
Gene symbol	Lyn
Other names/aliases	p53Lyn p56Lyn
Species	Rattus norvegicus
Database cross references - Lyn
ExoCarta	ExoCarta_81515
Vesiclepedia	VP_81515
Entrez Gene	81515
UniProt	Q07014
Lyn identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Lyn

Molecular Function     protein kinase activity GO:0004672 ISO     protein tyrosine kinase activity GO:0004713 IDA     protein tyrosine kinase activity GO:0004713 ISO     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     non-membrane spanning protein tyrosine kinase activity GO:0004715 ISO     signaling receptor binding GO:0005102 IBA     signaling receptor binding GO:0005102 IPI     platelet-derived growth factor receptor binding GO:0005161 IPI     integrin binding GO:0005178 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     kinase activity GO:0016301 TAS     SH3 domain binding GO:0017124 ISO     enzyme binding GO:0019899 IPI     enzyme binding GO:0019899 ISO     ubiquitin protein ligase binding GO:0031625 IPI     histone H3Y41 kinase activity GO:0035401 IEA     gamma-tubulin binding GO:0043015 IDA     glycosphingolipid binding GO:0043208 IPI     transmembrane transporter binding GO:0044325 ISO     protein-containing complex binding GO:0044877 IDA     protein-containing complex binding GO:0044877 IPI     protein-containing complex binding GO:0044877 ISO     ephrin receptor binding GO:0046875 ISO     phosphoprotein binding GO:0051219 IPI     scaffold protein binding GO:0097110 ISO     phosphorylation-dependent protein binding GO:0140031 ISO     histone H2AXY142 kinase activity GO:0140801 IEA     phosphatidylinositol 3-kinase activator activity GO:0141038 ISO Biological Process     DNA damage checkpoint signaling GO:0000077 ISO     cell morphogenesis GO:0000902 ISO     B cell homeostasis GO:0001782 ISO     B cell homeostasis GO:0001782 ISS     regulation of cytokine production GO:0001817 ISO     regulation of cytokine production GO:0001817 ISS     negative regulation of protein phosphorylation GO:0001933 ISO     negative regulation of protein phosphorylation GO:0001933 ISS     positive regulation of protein phosphorylation GO:0001934 ISO     hematopoietic progenitor cell differentiation GO:0002244 ISO     adaptive immune response GO:0002250 IEA     Fc receptor mediated stimulatory signaling pathway GO:0002431 IBA     Fc receptor mediated stimulatory signaling pathway GO:0002431 ISO     Fc receptor mediated stimulatory signaling pathway GO:0002431 ISS     tolerance induction to self antigen GO:0002513 IBA     tolerance induction to self antigen GO:0002513 ISO     tolerance induction to self antigen GO:0002513 ISS     histamine secretion by mast cell GO:0002553 IMP     platelet degranulation GO:0002576 ISO     platelet degranulation GO:0002576 ISS     negative regulation of myeloid leukocyte differentiation GO:0002762 ISO     immune response-regulating cell surface receptor signaling pathway GO:0002768 ISO     immune response-regulating cell surface receptor signaling pathway GO:0002768 ISS     Fc receptor mediated inhibitory signaling pathway GO:0002774 ISO     Fc receptor mediated inhibitory signaling pathway GO:0002774 ISS     regulation of B cell apoptotic process GO:0002902 ISO     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 ISO     autophagy GO:0006914 ISO     DNA damage response GO:0006974 IBA     DNA damage response GO:0006974 ISO     response to sterol depletion GO:0006991 IEP     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 ISO     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell population proliferation GO:0008284 ISS     negative regulation of cell population proliferation GO:0008285 ISO     negative regulation of cell population proliferation GO:0008285 ISS     response to xenobiotic stimulus GO:0009410 IEP     response to toxic substance GO:0009636 IEP     response to hormone GO:0009725 ISO     response to hormone GO:0009725 ISS     response to carbohydrate GO:0009743 IEP     positive regulation of neuron projection development GO:0010976 ISO     oligodendrocyte development GO:0014003 IEP     response to organic cyclic compound GO:0014070 IEP     fatty acid transport GO:0015908 ISO     peptidyl-tyrosine phosphorylation GO:0018108 ISO     peptidyl-tyrosine phosphorylation GO:0018108 ISO     hemopoiesis GO:0030097 ISO     erythrocyte differentiation GO:0030218 ISO     erythrocyte differentiation GO:0030218 ISS     eosinophil differentiation GO:0030222 ISO     positive regulation of cell migration GO:0030335 ISO     negative regulation of B cell proliferation GO:0030889 ISO     neuron projection development GO:0031175 IBA     neuron projection development GO:0031175 ISO     lipopolysaccharide-mediated signaling pathway GO:0031663 ISO     lipopolysaccharide-mediated signaling pathway GO:0031663 ISS     response to insulin GO:0032868 IEP     regulation of mast cell activation GO:0033003 ISO     regulation of mast cell activation GO:0033003 ISS     regulation of cell adhesion mediated by integrin GO:0033628 ISO     negative regulation of toll-like receptor 2 signaling pathway GO:0034136 ISO     negative regulation of toll-like receptor 2 signaling pathway GO:0034136 ISS     toll-like receptor 4 signaling pathway GO:0034142 ISO     negative regulation of toll-like receptor 4 signaling pathway GO:0034144 ISO     negative regulation of toll-like receptor 4 signaling pathway GO:0034144 ISS     cellular response to heat GO:0034605 IEP     intracellular signal transduction GO:0035556 ISO     interleukin-5-mediated signaling pathway GO:0038043 ISO     C-X-C chemokine receptor CXCR4 signaling pathway GO:0038159 ISO     positive regulation of phosphorylation GO:0042327 IMP     response to amino acid GO:0043200 IEP     regulation of mast cell degranulation GO:0043304 ISO     regulation of mast cell degranulation GO:0043304 ISS     negative regulation of MAP kinase activity GO:0043407 ISO     negative regulation of MAP kinase activity GO:0043407 ISS     positive regulation of MAPK cascade GO:0043410 ISO     response to peptide hormone GO:0043434 IEP     regulation of erythrocyte differentiation GO:0045646 ISO     regulation of erythrocyte differentiation GO:0045646 ISS     protein autophosphorylation GO:0046777 ISO     protein autophosphorylation GO:0046777 ISO     response to axon injury GO:0048678 IEP     regulation of inflammatory response GO:0050727 ISO     B cell receptor signaling pathway GO:0050853 ISO     regulation of B cell receptor signaling pathway GO:0050855 IBA     regulation of B cell receptor signaling pathway GO:0050855 ISO     regulation of B cell receptor signaling pathway GO:0050855 ISS     regulation of release of sequestered calcium ion into cytosol GO:0051279 IMP     regulation of release of sequestered calcium ion into cytosol GO:0051279 ISO     positive regulation of glial cell proliferation GO:0060252 IDA     positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0060369 IMP     regulation of ERK1 and ERK2 cascade GO:0070372 ISO     regulation of ERK1 and ERK2 cascade GO:0070372 ISS     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISO     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISS     positive regulation of oligodendrocyte progenitor proliferation GO:0070447 IMP     negative regulation of mast cell proliferation GO:0070667 ISO     negative regulation of mast cell proliferation GO:0070667 ISS     positive regulation of mast cell proliferation GO:0070668 ISO     cellular response to retinoic acid GO:0071300 ISO     regulation of monocyte chemotaxis GO:0090025 ISO     regulation of platelet aggregation GO:0090330 ISO     regulation of platelet aggregation GO:0090330 ISS     dendritic cell differentiation GO:0097028 IBA     dendritic cell differentiation GO:0097028 ISO     dendritic cell differentiation GO:0097028 ISS     neuroinflammatory response GO:0150076 ISO     negative regulation of intracellular signal transduction GO:1902532 ISO     negative regulation of intracellular signal transduction GO:1902532 ISS     positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961 ISO     positive regulation of dendritic cell apoptotic process GO:2000670 ISO     positive regulation of dendritic cell apoptotic process GO:2000670 ISS Subcellular Localization     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     Golgi apparatus GO:0005794 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISO     adherens junction GO:0005912 IDA     cytoplasmic side of plasma membrane GO:0009898 ISO     mitochondrial crista GO:0030061 IDA     mitochondrial membrane GO:0031966 IDA     protein-containing complex GO:0032991 ISO     integrin alpha2-beta1 complex GO:0034666 IDA     intracellular membrane-bounded organelle GO:0043231 ISO     membrane raft GO:0045121 ISO     perinuclear region of cytoplasm GO:0048471 IDA     perinuclear region of cytoplasm GO:0048471 ISO     glutamatergic synapse GO:0098978 IDA     postsynaptic specialization, intracellular component GO:0099091 IDA