Gene description for Lyn
Gene name	LYN proto-oncogene, Src family tyrosine kinase
Gene symbol	Lyn
Other names/aliases	p53Lyn p56Lyn
Species	Rattus norvegicus
Database cross references - Lyn
ExoCarta	ExoCarta_81515
Entrez Gene	81515
UniProt	Q07014
Lyn identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Lyn

Molecular Function     kinase activity GO:0016301 TAS     ATP binding GO:0005524 IEA     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     protein kinase activity GO:0004672 ISO     protein binding GO:0005515 IPI     protein tyrosine kinase activity GO:0004713 ISO     integrin binding GO:0005178 IDA     ubiquitin protein ligase binding GO:0031625 IPI     enzyme binding GO:0019899 ISO     glycosphingolipid binding GO:0043208 IPI     gamma-tubulin binding GO:0043015 IDA     ion channel binding GO:0044325 ISO     phosphoprotein binding GO:0051219 IPI     platelet-derived growth factor receptor binding GO:0005161 IPI     protein complex binding GO:0032403 ISO     SH3 domain binding GO:0017124 ISO     receptor binding GO:0005102 IPI Biological Process     erythrocyte differentiation GO:0030218 ISS     response to insulin GO:0032868 IEP     protein autophosphorylation GO:0046777 ISO     negative regulation of intracellular signal transduction GO:1902532 ISS     regulation of ERK1 and ERK2 cascade GO:0070372 ISS     lipopolysaccharide-mediated signaling pathway GO:0031663 ISS     regulation of mast cell activation GO:0033003 ISS     response to drug GO:0042493 IEP     positive regulation of phosphorylation GO:0042327 IMP     dendritic cell differentiation GO:0097028 ISS     negative regulation of cell proliferation GO:0008285 ISS     cellular response to heat GO:0034605 IEP     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISS     cellular response to peptide hormone stimulus GO:0071375 IBA     response to toxic substance GO:0009636 IEP     B cell homeostasis GO:0001782 ISS     regulation of B cell receptor signaling pathway GO:0050855 ISS     Fc receptor mediated stimulatory signaling pathway GO:0002431 ISS     cellular response to extracellular stimulus GO:0031668 IEP     positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0060369 IMP     innate immune response GO:0045087 IBA     regulation of platelet aggregation GO:0090330 ISS     immune response-regulating cell surface receptor signaling pathway GO:0002768 ISS     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     negative regulation of myeloid leukocyte differentiation GO:0002762 ISO     regulation of cytokine secretion GO:0050707 ISO     regulation of cell adhesion mediated by integrin GO:0033628 ISO     response to carbohydrate GO:0009743 IEP     positive regulation of glial cell proliferation GO:0060252 IDA     negative regulation of B cell proliferation GO:0030889 ISO     regulation of monocyte chemotaxis GO:0090025 ISO     negative regulation of mast cell proliferation GO:0070667 ISS     regulation of erythrocyte differentiation GO:0045646 ISS     positive regulation of dendritic cell apoptotic process GO:2000670 ISS     cellular response to DNA damage stimulus GO:0006974 ISO     positive regulation of cellular component movement GO:0051272 ISO     response to sterol depletion GO:0006991 IEP     response to amino acid GO:0043200 IEP     response to axon injury GO:0048678 IEP     positive regulation of neuron projection development GO:0010976 ISO     regulation of B cell apoptotic process GO:0002902 ISO     response to hormone GO:0009725 ISS     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 ISO     cellular response to retinoic acid GO:0071300 ISO     negative regulation of protein phosphorylation GO:0001933 ISS     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     negative regulation of toll-like receptor 4 signaling pathway GO:0034144 ISS     positive regulation of stress-activated protein kinase signaling cascade GO:0070304 ISO     response to peptide hormone GO:0043434 IEP     negative regulation of MAP kinase activity GO:0043407 ISS     oligodendrocyte development GO:0014003 IEP     peptidyl-tyrosine phosphorylation GO:0018108 ISO     protein phosphorylation GO:0006468 ISO     regulation of cytokine production GO:0001817 ISS     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 ISO     positive regulation of oligodendrocyte progenitor proliferation GO:0070447 IMP     hemopoiesis GO:0030097 ISO     positive regulation of B cell receptor signaling pathway GO:0050861 ISO     positive regulation of cell migration GO:0030335 ISO     histamine secretion by mast cell GO:0002553 IMP     positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 ISS     response to organic cyclic compound GO:0014070 IEP     platelet degranulation GO:0002576 ISS     Fc receptor mediated inhibitory signaling pathway GO:0002774 ISS     regulation of inflammatory response GO:0050727 ISO     tolerance induction to self antigen GO:0002513 ISS     cytokine secretion GO:0050663 IMP     regulation of mast cell degranulation GO:0043304 ISS     regulation of release of sequestered calcium ion into cytosol GO:0051279 ISO     intracellular signal transduction GO:0035556 ISO     B cell receptor signaling pathway GO:0050853 ISO     negative regulation of toll-like receptor 2 signaling pathway GO:0034136 ISS     positive regulation of cell proliferation GO:0008284 ISS     neuron projection development GO:0031175 ISO     positive regulation of mast cell proliferation GO:0070668 ISO Subcellular Localization     perinuclear region of cytoplasm GO:0048471 ISO     plasma membrane GO:0005886 ISO     mitochondrial membrane GO:0031966 IDA     integrin alpha2-beta1 complex GO:0034666 IDA     Golgi apparatus GO:0005794 ISO     membrane raft GO:0045121 ISO     mitochondrial crista GO:0030061 IDA     mast cell granule GO:0042629 IMP     postsynaptic density GO:0014069 IDA     extracellular exosome GO:0070062 ISO     cell GO:0005623 ISO     cell-cell adherens junction GO:0005913 IDA     nucleus GO:0005634 ISS     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA     cytoplasm GO:0005737 ISS     membrane GO:0016020 IDA     mitochondrial intermembrane space GO:0005758 IDA