Gene description for GTF3A
Gene name general transcription factor IIIA
Gene symbol GTF3A
Other names/aliases AP2
TFIIIA
Species Homo sapiens
 Database cross references - GTF3A
ExoCarta ExoCarta_2971
Entrez Gene 2971
HGNC 4662
MIM 600860
UniProt Q92664  
 GTF3A identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for GTF3A
Molecular Function
    DNA binding GO:0003677 IEA
    metal ion binding GO:0046872 IEA
    RNA binding GO:0003723 IEA
Biological Process
    gene expression GO:0010467 TAS
    transcription from RNA polymerase III promoter GO:0006383 TAS
    regulation of transcription, DNA-templated GO:0006355 IEA
    rRNA transcription GO:0009303 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 IDA
 Experiment description of studies that identified GTF3A in exosomes
1
Experiment ID 234
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for GTF3A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OPTN 10133
Invitro Homo sapiens
2 RALBP1  
Affinity Capture-Western Homo sapiens
3 HIP1 3092
Invivo Homo sapiens
Invitro Homo sapiens
4 EPN1  
Affinity Capture-Western Homo sapiens
5 IL8RB  
Affinity Capture-Western Homo sapiens
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