Gene description for IL6
Gene name	interleukin 6
Gene symbol	IL6
Other names/aliases	BSF2 HGF HSF IFNB2 IL-6
Species	Homo sapiens
Database cross references - IL6
ExoCarta	ExoCarta_3569
Vesiclepedia	VP_3569
Entrez Gene	3569
HGNC	6018
MIM	147620
UniProt	P05231
IL6 identified in sEVs derived from the following tissue/cell type
Fibroblasts	36266345
Fibroblasts	36266345
Fibroblasts	36266345
Fibroblasts	36266345
Fibroblasts	36266345
Fibroblasts	36266345
Fibroblasts	36266345
Fibroblasts	36266345
Fibroblasts	36266345
Plasma	34112803

Gene ontology annotations for IL6

Molecular Function     cytokine activity GO:0005125 IBA     cytokine activity GO:0005125 IDA     cytokine activity GO:0005125 ISS     cytokine activity GO:0005125 NAS     cytokine activity GO:0005125 TAS     interleukin-6 receptor binding GO:0005138 IPI     interleukin-6 receptor binding GO:0005138 IPI     interleukin-6 receptor binding GO:0005138 NAS     protein binding GO:0005515 IPI     growth factor activity GO:0008083 IBA     growth factor activity GO:0008083 IDA     identical protein binding GO:0042802 IPI Biological Process     neutrophil apoptotic process GO:0001781 IDA     germinal center B cell differentiation GO:0002314 ISS     hepatic immune response GO:0002384 IDA     hepatic immune response GO:0002384 TAS     neutrophil mediated immunity GO:0002446 TAS     monocyte chemotaxis GO:0002548 IC     positive regulation of immunoglobulin production GO:0002639 IDA     positive regulation of immunoglobulin production GO:0002639 ISS     positive regulation of acute inflammatory response GO:0002675 IDA     positive regulation of leukocyte chemotaxis GO:0002690 TAS     acute-phase response GO:0006953 TAS     inflammatory response GO:0006954 IDA     inflammatory response GO:0006954 TAS     humoral immune response GO:0006959 IC     cell surface receptor signaling pathway via JAK-STAT GO:0007259 IMP     positive regulation of cell population proliferation GO:0008284 IBA     positive regulation of cell population proliferation GO:0008284 IDA     positive regulation of cell population proliferation GO:0008284 IGI     positive regulation of cell population proliferation GO:0008284 IMP     negative regulation of cell population proliferation GO:0008285 TAS     vascular endothelial growth factor production GO:0010573 IDA     regulation of vascular endothelial growth factor production GO:0010574 IDA     positive regulation of vascular endothelial growth factor production GO:0010575 IMP     positive regulation of gene expression GO:0010628 IDA     positive regulation of gene expression GO:0010628 IGI     positive regulation of epithelial to mesenchymal transition GO:0010718 IDA     negative regulation of lipid storage GO:0010888 NAS     response to activity GO:0014823 ISS     cytokine-mediated signaling pathway GO:0019221 IDA     platelet activation GO:0030168 TAS     endocrine pancreas development GO:0031018 ISS     neuron projection development GO:0031175 IMP     response to peptidoglycan GO:0032494 NAS     negative regulation of chemokine production GO:0032682 ISS     positive regulation of chemokine production GO:0032722 IDA     positive regulation of chemokine production GO:0032722 NAS     positive regulation of interleukin-1 beta production GO:0032731 IGI     positive regulation of interleukin-10 production GO:0032733 IDA     positive regulation of interleukin-17 production GO:0032740 ISS     positive regulation of interleukin-21 production GO:0032745 ISS     positive regulation of interleukin-6 production GO:0032755 IDA     positive regulation of interleukin-8 production GO:0032757 IDA     positive regulation of tumor necrosis factor production GO:0032760 IDA     negative regulation of collagen biosynthetic process GO:0032966 IDA     positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA     maintenance of blood-brain barrier GO:0035633 TAS     positive regulation of T cell proliferation GO:0042102 IDA     glucose homeostasis GO:0042593 IDA     positive regulation of apoptotic process GO:0043065 IDA     negative regulation of apoptotic process GO:0043066 IDA     positive regulation of MAPK cascade GO:0043410 IDA     positive regulation of MAPK cascade GO:0043410 IDA     negative regulation of fat cell differentiation GO:0045599 NAS     positive regulation of osteoblast differentiation GO:0045669 TAS     positive regulation of translation GO:0045727 IDA     regulation of angiogenesis GO:0045765 IC     negative regulation of bone resorption GO:0045779 ISS     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of DNA-templated transcription GO:0045893 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IBA     positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IC     positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IDA     positive regulation of smooth muscle cell proliferation GO:0048661 IDA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     negative regulation of neurogenesis GO:0050768 TAS     regulation of insulin secretion GO:0050796 IDA     defense response to Gram-negative bacterium GO:0050829 TAS     defense response to Gram-positive bacterium GO:0050830 TAS     positive regulation of B cell activation GO:0050871 IDA     positive regulation of DNA-binding transcription factor activity GO:0051091 IDA     response to glucocorticoid GO:0051384 IDA     defense response to virus GO:0051607 IDA     positive regulation of glial cell proliferation GO:0060252 IDA     T follicular helper cell differentiation GO:0061470 ISS     regulation of astrocyte activation GO:0061888 TAS     neuron cellular homeostasis GO:0070050 TAS     glucagon secretion GO:0070091 ISS     regulation of glucagon secretion GO:0070092 IDA     interleukin-6-mediated signaling pathway GO:0070102 IDA     interleukin-6-mediated signaling pathway GO:0070102 IMP     interleukin-6-mediated signaling pathway GO:0070102 ISS     cellular response to hydrogen peroxide GO:0070301 IDA     cellular response to lipopolysaccharide GO:0071222 IMP     T-helper 17 cell lineage commitment GO:0072540 ISS     hepatocyte proliferation GO:0072574 ISS     positive regulation of extracellular matrix disassembly GO:0090091 IMP     inflammatory response to wounding GO:0090594 IDA     liver regeneration GO:0097421 ISS     cell surface receptor signaling pathway via STAT GO:0097696 IDA     cell surface receptor signaling pathway via STAT GO:0097696 IMP     cellular response to virus GO:0098586 ISS     regulation of neuroinflammatory response GO:0150077 TAS     positive regulation of neuroinflammatory response GO:0150078 TAS     positive regulation of cytokine production involved in inflammatory response GO:1900017 IGI     positive regulation of platelet aggregation GO:1901731 IDA     positive regulation of apoptotic DNA fragmentation GO:1902512 IMP     positive regulation of miRNA transcription GO:1902895 IDA     regulation of microglial cell activation GO:1903978 TAS     positive regulation of receptor signaling pathway via STAT GO:1904894 IGI     positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 IDA     positive regulation of T-helper 2 cell cytokine production GO:2000553 ISS     negative regulation of primary miRNA processing GO:2000635 IGI     negative regulation of interleukin-1-mediated signaling pathway GO:2000660 ISS     positive regulation of type B pancreatic cell apoptotic process GO:2000676 TAS Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 IDA     endoplasmic reticulum lumen GO:0005788 TAS     interleukin-6 receptor complex GO:0005896 IBA     interleukin-6 receptor complex GO:0005896 IDA