Gene description for IL6
Gene name	interleukin 6
Gene symbol	IL6
Other names/aliases	BSF2 HGF HSF IFNB2 IL-6
Species	Homo sapiens
Database cross references - IL6
ExoCarta	ExoCarta_3569
Vesiclepedia	VP_3569
Entrez Gene	3569
HGNC	6018
MIM	147620
UniProt	P05231
IL6 identified in exosomes derived from the following tissue/cell type
Plasma	34112803

Gene ontology annotations for IL6

Molecular Function     cytokine activity GO:0005125 NAS     growth factor activity GO:0008083 IDA     interleukin-6 receptor binding GO:0005138 NAS     protein binding GO:0005515 IPI Biological Process     response to calcium ion GO:0051592 IEA     positive regulation of T cell proliferation GO:0042102 IDA     positive regulation of immunoglobulin secretion GO:0051024 IDA     positive regulation of B cell activation GO:0050871 IDA     negative regulation of chemokine biosynthetic process GO:0045079 ISS     positive regulation of leukocyte chemotaxis GO:0002690 TAS     positive regulation of epithelial cell proliferation GO:0050679 IEA     cellular response to dexamethasone stimulus GO:0071549 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     response to drug GO:0042493 IEA     defense response to Gram-positive bacterium GO:0050830 TAS     regulation of angiogenesis GO:0045765 IC     positive regulation of neuron differentiation GO:0045666 IEA     response to amino acid GO:0043200 IEA     negative regulation of hormone secretion GO:0046888 IEA     negative regulation of lipid storage GO:0010888 NAS     response to caffeine GO:0031000 IEA     response to auditory stimulus GO:0010996 IEA     positive regulation of STAT protein import into nucleus GO:2000366 IC     negative regulation of neuron death GO:1901215 IEA     regulation of cell shape GO:0008360 IEA     cellular response to interleukin-6 GO:0071354 NAS     positive regulation of interleukin-6 production GO:0032755 IDA     branching involved in salivary gland morphogenesis GO:0060445 IEA     negative regulation of collagen biosynthetic process GO:0032966 IDA     positive regulation of osteoblast differentiation GO:0045669 TAS     inflammatory response GO:0006954 IDA     response to insulin GO:0032868 IEA     hepatic immune response GO:0002384 TAS     endocrine pancreas development GO:0031018 ISS     aging GO:0007568 IEA     positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA     interleukin-6-mediated signaling pathway GO:0070102 IDA     negative regulation of muscle organ development GO:0048635 IEA     positive regulation of apoptotic process GO:0043065 IDA     defense response to protozoan GO:0042832 IEA     epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     neuron projection development GO:0031175 IMP     positive regulation of T-helper 2 cell differentiation GO:0045630 IEA     neutrophil apoptotic process GO:0001781 IDA     defense response to virus GO:0051607 IDA     response to heat GO:0009408 IEA     positive regulation of smooth muscle cell proliferation GO:0048661 IDA     humoral immune response GO:0006959 IC     positive regulation of DNA replication GO:0045740 IEA     cell redox homeostasis GO:0045454 IEA     muscle cell cellular homeostasis GO:0046716 IEA     glucose homeostasis GO:0042593 IEA     positive regulation of protein kinase B signaling GO:0051897 IEA     response to electrical stimulus GO:0051602 IEA     positive regulation of transcription, DNA-templated GO:0045893 IDA     response to cold GO:0009409 IEA     cell growth GO:0016049 IEA     bone remodeling GO:0046849 IEA     negative regulation of cell proliferation GO:0008285 IEA     negative regulation of gluconeogenesis GO:0045721 IEA     T-helper 17 cell lineage commitment GO:0072540 ISS     positive regulation of nitric oxide biosynthetic process GO:0045429 IEA     response to antibiotic GO:0046677 IEA     defense response to Gram-negative bacterium GO:0050829 TAS     positive regulation of acute inflammatory response GO:0002675 IDA     acute-phase response GO:0006953 TAS     cellular response to hydrogen peroxide GO:0070301 IDA     positive regulation of cell proliferation GO:0008284 IMP     positive regulation of translation GO:0045727 IDA     response to peptidoglycan GO:0032494 NAS     regulation of vascular endothelial growth factor production GO:0010574 IDA     cellular response to lipopolysaccharide GO:0071222 IMP     cellular response to interleukin-1 GO:0071347 IEA     cytokine-mediated signaling pathway GO:0019221 IDA     platelet activation GO:0030168 TAS     negative regulation of protein kinase activity GO:0006469 IEA     positive regulation of transmission of nerve impulse GO:0051971 IEA     positive regulation of type B pancreatic cell apoptotic process GO:2000676 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 NAS     positive regulation of JAK-STAT cascade GO:0046427 IDA     positive regulation of chemokine production GO:0032722 NAS     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IDA     positive regulation of protein import into nucleus, translocation GO:0033160 IEA     negative regulation of apoptotic process GO:0043066 IDA     regulation of circadian sleep/wake cycle, non-REM sleep GO:0045188 IEA     positive regulation of MAPK cascade GO:0043410 IDA     positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA     response to glucocorticoid GO:0051384 IDA     negative regulation of cytokine secretion GO:0050710 IEA     cellular response to tumor necrosis factor GO:0071356 IEA     monocyte chemotaxis GO:0002548 IC     positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 IDA     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IEA     response to nutrient levels GO:0031667 IEA     glucagon secretion GO:0070091 ISS     negative regulation of fat cell differentiation GO:0045599 NAS     neutrophil mediated immunity GO:0002446 TAS Subcellular Localization     extracellular region GO:0005576 TAS     external side of plasma membrane GO:0009897 IEA     extracellular space GO:0005615 IDA     cytoplasm GO:0005737 IEA     interleukin-6 receptor complex GO:0005896 IDA