Gene description for CXCL2
Gene name chemokine (C-X-C motif) ligand 2
Gene symbol CXCL2
Other names/aliases CINC-2a
GRO2
GROb
MGSA-b
MIP-2a
MIP2
MIP2A
SCYB2
Species Homo sapiens
 Database cross references - CXCL2
ExoCarta ExoCarta_2920
Entrez Gene 2920
HGNC 4603
MIM 139110
UniProt P19875  
 CXCL2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CXCL2
Molecular Function
    chemokine activity GO:0008009 IEA
    CXCR chemokine receptor binding GO:0045236 IBA
    protein binding GO:0005515 IPI
Biological Process
    response to molecule of bacterial origin GO:0002237 IDA
    chemokine-mediated signaling pathway GO:0070098 IBA
    inflammatory response GO:0006954 IEA
    regulation of cell proliferation GO:0042127 IBA
    chemotaxis GO:0006935 TAS
    immune response GO:0006955 IBA
    cell chemotaxis GO:0060326 TAS
    response to lipopolysaccharide GO:0032496 IBA
    G-protein coupled receptor signaling pathway GO:0007186 IBA
    positive regulation of leukocyte chemotaxis GO:0002690 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified CXCL2 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CXCL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IL8RA  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
2 IL8RB  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
3 CXCL2 2920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PLG 5340
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which CXCL2 is involved
PathwayEvidenceSource
Chemokine receptors bind chemokines TAS Reactome
G alpha (i) signalling events TAS Reactome





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