Gene description for Nfyc
Gene name nuclear transcription factor-Y gamma
Gene symbol Nfyc
Other names/aliases -
Species Mus musculus
 Database cross references - Nfyc
ExoCarta ExoCarta_18046
Vesiclepedia VP_18046
Entrez Gene 18046
UniProt P70353  
 Nfyc identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nfyc
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    transcription cis-regulatory region binding GO:0000976 ISO
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    DNA binding GO:0003677 ISO
    DNA-binding transcription factor activity GO:0003700 IDA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    regulation of DNA-templated transcription GO:0006355 ISO
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IC
    CCAAT-binding factor complex GO:0016602 IBA
    CCAAT-binding factor complex GO:0016602 ISO
    protein-DNA complex GO:0032993 IEA
    protein-DNA complex GO:0032993 ISO
    RNA polymerase II transcription regulator complex GO:0090575 ISO
 Experiment description of studies that identified Nfyc in exosomes
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nfyc
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MRPS12  
Affinity Capture-MS Homo sapiens
2 ARV1  
Affinity Capture-MS Homo sapiens
3 PCGF5  
Affinity Capture-MS Homo sapiens
4 Pou5f1  
Affinity Capture-MS Mus musculus
5 FOXRED2  
Affinity Capture-MS Homo sapiens
6 CDCA8 55143
Affinity Capture-MS Homo sapiens
7 TCTN3  
Affinity Capture-MS Homo sapiens
8 MED7  
Affinity Capture-MS Homo sapiens
9 MRPS15  
Affinity Capture-MS Homo sapiens
10 INCENP 3619
Affinity Capture-MS Homo sapiens
11 SHMT2 6472
Affinity Capture-MS Homo sapiens
12 SAMD4B  
Affinity Capture-MS Homo sapiens
13 HMGXB4 10042
Affinity Capture-MS Homo sapiens
14 BDP1  
Affinity Capture-MS Homo sapiens
15 ABCF2 10061
Affinity Capture-MS Homo sapiens
16 NFYB  
Affinity Capture-MS Homo sapiens
17 NKRF 55922
Affinity Capture-MS Homo sapiens
18 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
19 ACTR1A 10121
Affinity Capture-MS Homo sapiens
20 NFYA 4800
Affinity Capture-MS Homo sapiens
21 PRSS23 11098
Affinity Capture-MS Homo sapiens
22 BRD3 8019
Affinity Capture-MS Homo sapiens
23 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Nfyc is involved
No pathways found





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