Gene description for Nfyc
Gene name nuclear transcription factor-Y gamma
Gene symbol Nfyc
Other names/aliases -
Species Mus musculus
 Database cross references - Nfyc
ExoCarta ExoCarta_18046
Entrez Gene 18046
UniProt P70353  
 Nfyc identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nfyc
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    transcription factor binding GO:0008134 ISO
    transcription regulatory region DNA binding GO:0044212 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    sequence-specific DNA binding GO:0043565 IEA
    protein heterodimerization activity GO:0046982 IEA
    DNA binding GO:0003677 ISO
Biological Process
    transcription from RNA polymerase II promoter GO:0006366 IDA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    regulation of transcription, DNA-templated GO:0006355 ISO
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    protein-DNA complex GO:0032993 ISO
    transcription factor complex GO:0005667 IC
    CCAAT-binding factor complex GO:0016602 ISO
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    intracellular GO:0005622 IEA
 Experiment description of studies that identified Nfyc in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nfyc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nfyc is involved
PathwayEvidenceSource
Activation of gene expression by SREBF (SREBP) IEA Reactome





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