Gene description for LRRC14
Gene name leucine rich repeat containing 14
Gene symbol LRRC14
Other names/aliases LRRC14A
Species Homo sapiens
 Database cross references - LRRC14
ExoCarta ExoCarta_9684
Vesiclepedia VP_9684
Entrez Gene 9684
HGNC 20419
UniProt Q15048  
 LRRC14 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LRRC14
Molecular Function
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 IBA
    kinase binding GO:0019900 IPI
Biological Process
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    negative regulation of toll-like receptor signaling pathway GO:0034122 IBA
    negative regulation of toll-like receptor signaling pathway GO:0034122 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified LRRC14 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRRC14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COPS5 10987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 TCEB1 6921
Affinity Capture-MS Homo sapiens
3 TCEB2 6923
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 COPS3 8533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 C9orf72  
Affinity Capture-MS Homo sapiens
6 RBX1 9978
Affinity Capture-MS Homo sapiens
7 CUL2 8453
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 COPS4 51138
Affinity Capture-MS Homo sapiens
9 IKBKB 3551
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 CHUK 1147
Affinity Capture-Western Homo sapiens
11 COPS6 10980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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