Gene description for Sep1
Gene name Septin 1
Gene symbol Sep1
Other names/aliases 38960
CG1403
Diff6
DmelCG1403
anon-19Fa
iby
sep1
tu1
Species Drosophila melanogaster
 Database cross references - Sep1
ExoCarta ExoCarta_33114
Entrez Gene 33114
UniProt P42207  
 Sep1 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Sep1
Molecular Function
    GTP binding GO:0005525 ISS
    protein homodimerization activity GO:0042803 IDA
    protein binding GO:0005515 IPI
    GTPase activity GO:0003924 NAS
    ubiquitin protein ligase binding GO:0031625 IPI
Biological Process
    mitotic cytokinesis GO:0000281 ISS
    positive regulation of apoptotic process GO:0043065 IDA
    cellularization GO:0007349 TAS
Subcellular Localization
    germline ring canal GO:0045172 NAS
    contractile ring GO:0070938 IDA
    septin ring GO:0005940 ISS
    microtubule associated complex GO:0005875 IDA
    septin complex GO:0031105 IPI
 Experiment description of studies that identified Sep1 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sep1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sep1 is involved
No pathways found





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