Gene description for Sep1
Gene name Septin 1
Gene symbol Sep1
Other names/aliases 38960
CG1403
Diff6
DmelCG1403
anon-19Fa
iby
sep1
tu1
Species Drosophila melanogaster
 Database cross references - Sep1
ExoCarta ExoCarta_33114
Vesiclepedia VP_33114
Entrez Gene 33114
UniProt P42207  
 Sep1 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Sep1
Molecular Function
    GTPase activity GO:0003924 IDA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IDA
    ubiquitin protein ligase binding GO:0031625 IPI
    protein homodimerization activity GO:0042803 IDA
Biological Process
    cellularization GO:0007349 TAS
    imaginal disc-derived wing morphogenesis GO:0007476 IMP
    positive regulation of apoptotic process GO:0043065 IDA
Subcellular Localization
    septin complex GO:0031105 IDA
    septin complex GO:0031105 IPI
    cleavage furrow GO:0032154 IDA
    contractile ring GO:0070938 HDA
 Experiment description of studies that identified Sep1 in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sep1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ef1alpha48D  
Two-hybrid Drosophila melanogaster
2 pnut 35801
Affinity Capture-MS Drosophila melanogaster
3 Sep2  
Two-hybrid Drosophila melanogaster
Affinity Capture-MS Drosophila melanogaster
4 STX1A 6804
Affinity Capture-Western Homo sapiens
5 Sep5  
Affinity Capture-MS Drosophila melanogaster
6 Pih1D1  
Two-hybrid Drosophila melanogaster
7 park  
Affinity Capture-Western Drosophila melanogaster
8 Sec16  
Two-hybrid Drosophila melanogaster
9 MED31  
Two-hybrid Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Sep1 is involved
No pathways found





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