Gene description for ZCCHC14
Gene name zinc finger, CCHC domain containing 14
Gene symbol ZCCHC14
Other names/aliases BDG-29
BDG29
Species Homo sapiens
 Database cross references - ZCCHC14
ExoCarta ExoCarta_23174
Vesiclepedia VP_23174
Entrez Gene 23174
HGNC 24134
UniProt Q8WYQ9  
 ZCCHC14 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ZCCHC14
Molecular Function
    nucleic acid binding GO:0003676 IEA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    phosphatidylinositol binding GO:0035091 IEA
 Experiment description of studies that identified ZCCHC14 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ZCCHC14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 PRR20C  
Two-hybrid Homo sapiens
4 PRR20A  
Two-hybrid Homo sapiens
5 MYOG  
Two-hybrid Homo sapiens
6 FHL3 2275
Two-hybrid Homo sapiens
7 SQSTM1 8878
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
8 PRR20D  
Two-hybrid Homo sapiens
9 USP54 159195
Two-hybrid Homo sapiens
10 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
11 PRR20B  
Two-hybrid Homo sapiens
12 PLEKHG4  
Two-hybrid Homo sapiens
13 PRR20E  
Two-hybrid Homo sapiens
14 CYSRT1 375791
Two-hybrid Homo sapiens
15 MYO15B 80022
Two-hybrid Homo sapiens
16 SMAD3 4088
Two-hybrid Homo sapiens
17 TNS2 23371
Two-hybrid Homo sapiens
18 ENPEP 2028
Affinity Capture-MS Homo sapiens
19 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
20 NFIC 4782
Two-hybrid Homo sapiens
21 GUSBP5  
Affinity Capture-MS Homo sapiens
22 Gsk3b  
Affinity Capture-MS Mus musculus
23 RMND5A 64795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZCCHC14 is involved
No pathways found





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