Gene description for ROMO1
Gene name reactive oxygen species modulator 1
Gene symbol ROMO1
Other names/aliases C20orf52
MTGM
MTGMP
bA353C18.2
Species Homo sapiens
 Database cross references - ROMO1
ExoCarta ExoCarta_140823
Vesiclepedia VP_140823
Entrez Gene 140823
HGNC 16185
UniProt P60602  
 ROMO1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ROMO1
Molecular Function
    protein binding GO:0005515 IPI
    monoatomic cation transmembrane transporter activity GO:0008324 IDA
Biological Process
    intracellular protein transport GO:0006886 NAS
    protein import into mitochondrial matrix GO:0030150 IBA
    killing of cells of another organism GO:0031640 IDA
    killing of cells of another organism GO:0031640 IMP
    cellular response to reactive oxygen species GO:0034614 IMP
    defense response to bacterium GO:0042742 IDA
    protein insertion into mitochondrial inner membrane GO:0045039 IBA
    protein insertion into mitochondrial inner membrane GO:0045039 IMP
    defense response to Gram-negative bacterium GO:0050829 IDA
    defense response to Gram-negative bacterium GO:0050829 IMP
    defense response to Gram-positive bacterium GO:0050830 IDA
    cytolysis by host of symbiont cells GO:0051838 IDA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IMP
    replicative senescence GO:0090399 IMP
    monoatomic cation transmembrane transport GO:0098655 IDA
    positive regulation of reactive oxygen species metabolic process GO:2000379 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 NAS
    TIM23 mitochondrial import inner membrane translocase complex GO:0005744 IBA
    TIM23 mitochondrial import inner membrane translocase complex GO:0005744 IDA
    TIM23 mitochondrial import inner membrane translocase complex GO:0005744 NAS
 Experiment description of studies that identified ROMO1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ROMO1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LDLR 3949
Positive Genetic Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 C15orf48  
Affinity Capture-MS Homo sapiens
4 CIDEB  
Two-hybrid Homo sapiens
5 NDUFA4 4697
Affinity Capture-MS Homo sapiens
6 TIMM17A  
Affinity Capture-MS Homo sapiens
7 ELOVL5 60481
Affinity Capture-MS Homo sapiens
8 DVL2 1856
Affinity Capture-MS Homo sapiens
9 COQ9  
Affinity Capture-MS Homo sapiens
10 NUP35 129401
Proximity Label-MS Homo sapiens
11 ERAP1 51752
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ROMO1 is involved
No pathways found





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