Gene description for CDH6
Gene name cadherin 6, type 2, K-cadherin (fetal kidney)
Gene symbol CDH6
Other names/aliases CAD6
KCAD
Species Homo sapiens
 Database cross references - CDH6
ExoCarta ExoCarta_1004
Entrez Gene 1004
HGNC 1765
MIM 603007
UniProt P55285  
 CDH6 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CDH6
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    cell junction assembly GO:0034329 TAS
    cell adhesion GO:0007155 TAS
    cell-cell junction organization GO:0045216 TAS
    adherens junction organization GO:0034332 TAS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified CDH6 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CDH6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDH10  
Invivo Homo sapiens
2 CDH6 1004
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
3 CDH18  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
4 CDH9 1007
Invivo Homo sapiens
5 CDH19  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
6 CDH7  
Invivo Homo sapiens
7 CTNNB1 1499
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CDH6 is involved
PathwayEvidenceSource
Adherens junctions interactions TAS Reactome





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