Gene description for SLC4A4
Gene name solute carrier family 4 (sodium bicarbonate cotransporter), member 4
Gene symbol SLC4A4
Other names/aliases HNBC1
Species Homo sapiens
 Database cross references - SLC4A4
ExoCarta ExoCarta_8671
Entrez Gene 8671
HGNC 11030
MIM 603345
UniProt Q9Y6R1  
 SLC4A4 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC4A4
Molecular Function
    sodium:bicarbonate symporter activity GO:0008510 IMP
    protein binding GO:0005515 IPI
    inorganic anion exchanger activity GO:0005452 IEA
Biological Process
    bicarbonate transport GO:0015701 TAS
    anion transmembrane transport GO:0098656 IBA
    transport GO:0006810 TAS
    transmembrane transport GO:0055085 TAS
    sodium ion transport GO:0006814 IDA
    sodium ion transmembrane transport GO:0035725 IMP
    ion transport GO:0006811 TAS
    regulation of intracellular pH GO:0051453 IBA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
    basolateral plasma membrane GO:0016323 IDA
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified SLC4A4 in exosomes
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC4A4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC4A7 9497
Invivo Homo sapiens
2 CA2 760
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SLC4A4 is involved
Bicarbonate transporters TAS Reactome

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