Gene description for GZMA
Gene name granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Gene symbol GZMA
Other names/aliases CTLA3
Species Homo sapiens
 Database cross references - GZMA
ExoCarta ExoCarta_3001
Entrez Gene 3001
HGNC 4708
MIM 140050
UniProt P12544  
 GZMA identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GZMA
Molecular Function
    protein homodimerization activity GO:0042803 IDA
    serine-type endopeptidase activity GO:0004252 IDA
    protein binding GO:0005515 IPI
Biological Process
    cytolysis GO:0019835 IEA
    positive regulation of apoptotic process GO:0043065 IDA
    negative regulation of oxidoreductase activity GO:0051354 IDA
    negative regulation of endodeoxyribonuclease activity GO:0032078 IDA
    apoptotic process GO:0006915 TAS
    negative regulation of DNA binding GO:0043392 IDA
    immune response GO:0006955 TAS
    proteolysis involved in cellular protein catabolic process GO:0051603 IDA
Subcellular Localization
    immunological synapse GO:0001772 TAS
    extracellular region GO:0005576 IEA
    nucleus GO:0005634 TAS
 Experiment description of studies that identified GZMA in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GZMA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SET 6418
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
2 NCL 4691
Affinity Capture-MS Homo sapiens
3 HMGB2 3148
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GZMA is involved
No pathways found

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