Gene description for ACADL
Gene name acyl-CoA dehydrogenase, long chain
Gene symbol ACADL
Other names/aliases ACAD4
LCAD
Species Homo sapiens
 Database cross references - ACADL
ExoCarta ExoCarta_33
Vesiclepedia VP_33
Entrez Gene 33
HGNC 88
MIM 609576
UniProt P28330  
 ACADL identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ACADL
Molecular Function
    fatty-acyl-CoA binding GO:0000062 IEA
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 IBA
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 IDA
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 ISS
    protein binding GO:0005515 IPI
    palmitoyl-CoA oxidase activity GO:0016401 IBA
    identical protein binding GO:0042802 IEA
    flavin adenine dinucleotide binding GO:0050660 IBA
Biological Process
    temperature homeostasis GO:0001659 ISS
    lipid catabolic process GO:0016042 ISS
    carnitine metabolic process, CoA-linked GO:0019254 IBA
    carnitine metabolic process, CoA-linked GO:0019254 ISS
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 IBA
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 ISS
    carnitine catabolic process GO:0042413 ISS
    long-chain fatty acid catabolic process GO:0042758 IBA
    negative regulation of fatty acid biosynthetic process GO:0045717 ISS
    negative regulation of fatty acid oxidation GO:0046322 ISS
    regulation of cholesterol metabolic process GO:0090181 ISS
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrial matrix GO:0005759 TAS
    mitochondrial membrane GO:0031966 IEA
 Experiment description of studies that identified ACADL in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ACADL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ZNF597  
Affinity Capture-MS Homo sapiens
3 TTC9C 283237
Affinity Capture-MS Homo sapiens
4 MTHFD2 10797
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ACTR3B 57180
Affinity Capture-MS Homo sapiens
6 GMFB 2764
Affinity Capture-MS Homo sapiens
7 SYT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 Htt  
Affinity Capture-MS Mus musculus
9 KLHDC2  
Affinity Capture-MS Homo sapiens
10 TNFAIP6 7130
Affinity Capture-MS Homo sapiens
11 ZC3H7A  
Affinity Capture-MS Homo sapiens
12 TMPRSS11A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 RAP1B 5908
Affinity Capture-MS Homo sapiens
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