Gene description for SLC5A5
Gene name solute carrier family 5 (sodium/iodide cotransporter), member 5
Gene symbol SLC5A5
Other names/aliases NIS
TDH1
Species Homo sapiens
 Database cross references - SLC5A5
ExoCarta ExoCarta_6528
Entrez Gene 6528
HGNC 11040
MIM 601843
UniProt Q92911  
 SLC5A5 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for SLC5A5
Molecular Function
    iodide transmembrane transporter activity GO:0015111 IMP
    sodium:iodide symporter activity GO:0008507 IEA
Biological Process
    transmembrane transport GO:0055085 TAS
    transport GO:0006810 TAS
    thyroid hormone generation GO:0006590 TAS
    cellular response to gonadotropin stimulus GO:0071371 IEP
    small molecule metabolic process GO:0044281 TAS
    iodide transport GO:0015705 IMP
    ion transport GO:0006811 TAS
    cellular nitrogen compound metabolic process GO:0034641 TAS
    sodium ion transmembrane transport GO:0035725 IEA
    anion transmembrane transport GO:0098656 IEA
    cellular response to cAMP GO:0071320 IEP
Subcellular Localization
    extracellular vesicle GO:1903561 IDA
    extracellular exosome GO:0070062 IDA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
    nucleus GO:0005634 IDA
 Experiment description of studies that identified SLC5A5 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for SLC5A5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC5A5 is involved
PathwayEvidenceSource
Organic anion transporters TAS Reactome
Thyroxine biosynthesis TAS Reactome





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