Gene description for ALPK1
Gene name alpha-kinase 1
Gene symbol ALPK1
Other names/aliases 8430410J10Rik
LAK
Species Homo sapiens
 Database cross references - ALPK1
ExoCarta ExoCarta_80216
Entrez Gene 80216
HGNC 20917
MIM 607347
UniProt Q96QP1  
 ALPK1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ALPK1
Molecular Function
    ATP binding GO:0005524 IEA
    protein serine/threonine kinase activity GO:0004674 IEA
Biological Process
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
    protein phosphorylation GO:0006468 IEA
    positive regulation of defense response to virus by host GO:0002230 IMP
 Experiment description of studies that identified ALPK1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ALPK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ALPK1 is involved
No pathways found





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