Gene description for IL10
Gene name interleukin 10
Gene symbol IL10
Other names/aliases CSIF
GVHDS
IL-10
IL10A
TGIF
Species Homo sapiens
 Database cross references - IL10
ExoCarta ExoCarta_3586
Vesiclepedia VP_3586
Entrez Gene 3586
HGNC 5962
MIM 124092
UniProt P22301  
 IL10 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IL10
Molecular Function
    cytokine activity GO:0005125 NAS
    interleukin-10 receptor binding GO:0005141 NAS
    growth factor activity GO:0008083 NAS
Biological Process
    leukocyte chemotaxis GO:0030595 TAS
    cellular response to lipopolysaccharide GO:0071222 NAS
    positive regulation of JAK-STAT cascade GO:0046427 IBA
    aging GO:0007568 IEA
    response to inactivity GO:0014854 IEA
    negative regulation of nitric oxide biosynthetic process GO:0045019 IEA
    negative regulation of interleukin-6 production GO:0032715 IDA
    negative regulation of endothelial cell apoptotic process GO:2000352 IMP
    negative regulation of cytokine secretion involved in immune response GO:0002740 IDA
    regulation of complement-dependent cytotoxicity GO:1903659 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    response to drug GO:0042493 IEA
    regulation of gene expression GO:0010468 IDA
    B cell differentiation GO:0030183 NAS
    positive regulation of cytokine secretion GO:0050715 IDA
    response to carbon monoxide GO:0034465 IEA
    response to glucocorticoid GO:0051384 IDA
    receptor biosynthetic process GO:0032800 IDA
    regulation of isotype switching GO:0045191 NAS
    positive regulation of B cell apoptotic process GO:0002904 IDA
    negative regulation of B cell proliferation GO:0030889 IDA
    response to insulin GO:0032868 IEA
    branching involved in labyrinthine layer morphogenesis GO:0060670 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    negative regulation of interferon-gamma production GO:0032689 IEA
    regulation of sensory perception of pain GO:0051930 IEA
    type 2 immune response GO:0042092 TAS
    negative regulation of apoptotic process GO:0043066 NAS
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IDA
    response to activity GO:0014823 IEA
    negative regulation of cytokine activity GO:0060302 IMP
    cell-cell signaling GO:0007267 IC
    negative regulation of interferon-alpha biosynthetic process GO:0045355 NAS
    positive regulation of MHC class II biosynthetic process GO:0045348 IEA
    hemopoiesis GO:0030097 TAS
    negative regulation of interleukin-12 production GO:0032695 IEA
    negative regulation of growth of symbiont in host GO:0044130 IEA
    negative regulation of chronic inflammatory response to antigenic stimulus GO:0002875 IEA
    defense response to bacterium GO:0042742 IEA
    response to molecule of bacterial origin GO:0002237 IDA
    negative regulation of T cell proliferation GO:0042130 NAS
    inflammatory response GO:0006954 IDA
    negative regulation of tumor necrosis factor biosynthetic process GO:0042536 IEA
    cytoplasmic sequestering of NF-kappaB GO:0007253 NAS
    cellular response to estradiol stimulus GO:0071392 IEA
    negative regulation of MHC class II biosynthetic process GO:0045347 TAS
    negative regulation of membrane protein ectodomain proteolysis GO:0051045 IDA
    B cell proliferation GO:0042100 NAS
    negative regulation of myeloid dendritic cell activation GO:0030886 IEA
Subcellular Localization
    extracellular space GO:0005615 IDA
    cytoplasm GO:0005737 NAS
 Experiment description of studies that identified IL10 in exosomes
1
Experiment ID 126
MISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IL10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 A2M 2
Invitro Homo sapiens
2 IL10RB 3588
Invivo Homo sapiens
Invitro Homo sapiens
3 IL10 3586
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
4 IL10RA  
Co-purification Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which IL10 is involved
No pathways found





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