Gene description for IL10
Gene name	interleukin 10
Gene symbol	IL10
Other names/aliases	CSIF GVHDS IL-10 IL10A TGIF
Species	Homo sapiens
Database cross references - IL10
ExoCarta	ExoCarta_3586
Vesiclepedia	VP_3586
Entrez Gene	3586
HGNC	5962
MIM	124092
UniProt	P22301
IL10 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for IL10

Molecular Function     cytokine activity GO:0005125 IDA     cytokine activity GO:0005125 NAS     interleukin-10 receptor binding GO:0005141 NAS     protein binding GO:0005515 IPI     growth factor activity GO:0008083 NAS     protein dimerization activity GO:0046983 IDA Biological Process     negative regulation of cytokine production GO:0001818 IDA     positive regulation of cytokine production GO:0001819 IDA     positive regulation of endothelial cell proliferation GO:0001938 IEA     response to molecule of bacterial origin GO:0002237 IDA     chronic inflammatory response to antigenic stimulus GO:0002439 IEA     positive regulation of immunoglobulin production GO:0002639 IGI     negative regulation of cytokine production involved in immune response GO:0002719 IDA     negative regulation of chronic inflammatory response to antigenic stimulus GO:0002875 IEA     positive regulation of B cell apoptotic process GO:0002904 IDA     cytoplasmic sequestering of NF-kappaB GO:0007253 NAS     negative regulation of cell population proliferation GO:0008285 ISS     response to xenobiotic stimulus GO:0009410 IEA     regulation of gene expression GO:0010468 IDA     negative regulation of autophagy GO:0010507 IDA     response to activity GO:0014823 IEA     response to inactivity GO:0014854 IEA     hemopoiesis GO:0030097 TAS     B cell differentiation GO:0030183 NAS     leukocyte chemotaxis GO:0030595 TAS     negative regulation of myeloid dendritic cell activation GO:0030886 IEA     negative regulation of B cell proliferation GO:0030889 IDA     negative regulation of interferon-alpha production GO:0032687 NAS     negative regulation of type II interferon production GO:0032689 IEA     negative regulation of interleukin-1 production GO:0032692 TAS     negative regulation of interleukin-12 production GO:0032695 TAS     negative regulation of interleukin-18 production GO:0032701 TAS     negative regulation of interleukin-6 production GO:0032715 IDA     negative regulation of interleukin-6 production GO:0032715 TAS     negative regulation of interleukin-8 production GO:0032717 TAS     negative regulation of tumor necrosis factor production GO:0032720 TAS     response to insulin GO:0032868 IEA     negative regulation of heterotypic cell-cell adhesion GO:0034115 ISS     positive regulation of heterotypic cell-cell adhesion GO:0034116 ISS     response to carbon monoxide GO:0034465 IEA     cellular response to hepatocyte growth factor stimulus GO:0035729 IEA     type 2 immune response GO:0042092 TAS     B cell proliferation GO:0042100 NAS     negative regulation of T cell proliferation GO:0042130 NAS     defense response to bacterium GO:0042742 IEA     defense response to protozoan GO:0042832 IEA     positive regulation of macrophage activation GO:0043032 IEA     negative regulation of apoptotic process GO:0043066 NAS     negative regulation of nitric oxide biosynthetic process GO:0045019 IEA     regulation of isotype switching GO:0045191 NAS     negative regulation of MHC class II biosynthetic process GO:0045347 IDA     negative regulation of MHC class II biosynthetic process GO:0045347 TAS     positive regulation of MHC class II biosynthetic process GO:0045348 IEA     positive regulation of cell cycle GO:0045787 IEA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of DNA-templated transcription GO:0045893 IMP     negative regulation of mitotic cell cycle GO:0045930 ISS     positive regulation of transcription by RNA polymerase II GO:0045944 IEA     positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IDA     negative regulation of inflammatory response GO:0050728 IDA     negative regulation of inflammatory response GO:0050728 NAS     regulation of synapse organization GO:0050807 IEA     negative regulation of membrane protein ectodomain proteolysis GO:0051045 IDA     positive regulation of DNA-binding transcription factor activity GO:0051091 IDA     response to glucocorticoid GO:0051384 IDA     negative regulation of cytokine activity GO:0060302 IMP     branching involved in labyrinthine layer morphogenesis GO:0060670 IEA     cellular response to lipopolysaccharide GO:0071222 IDA     cellular response to lipopolysaccharide GO:0071222 NAS     cellular response to estradiol stimulus GO:0071392 IEA     negative regulation of chemokine (C-C motif) ligand 5 production GO:0071650 TAS     endothelial cell apoptotic process GO:0072577 ISS     liver regeneration GO:0097421 IEA     interleukin-10-mediated signaling pathway GO:0140105 IDA     positive regulation of plasma cell differentiation GO:1900100 IGI     positive regulation of miRNA transcription GO:1902895 IDA     regulation of response to wounding GO:1903034 ISS     negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 IEA     regulation of complement-dependent cytotoxicity GO:1903659 IMP     positive regulation of sprouting angiogenesis GO:1903672 IEA     negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 ISS     positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 ISS     positive regulation of signaling receptor activity GO:2000273 IDA     negative regulation of endothelial cell apoptotic process GO:2000352 IMP Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IDA     extracellular space GO:0005615 IDA