Gene description for CES3
Gene name carboxylesterase 3
Gene symbol CES3
Other names/aliases ES31
Species Homo sapiens
 Database cross references - CES3
ExoCarta ExoCarta_23491
Vesiclepedia VP_23491
Entrez Gene 23491
HGNC 1865
MIM 605279
UniProt Q6UWW8  
 CES3 identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for CES3
Molecular Function
    carboxylic ester hydrolase activity GO:0052689 TAS
    carboxylesterase activity GO:0106435 IEA
Biological Process
    xenobiotic metabolic process GO:0006805 TAS
    low-density lipoprotein particle clearance GO:0034383 TAS
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 IEA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CES3 in sEVs
1
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for CES3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 DEFB106A  
Affinity Capture-MS Homo sapiens
3 TMEM25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PTPRK 5796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 MCU 90550
Affinity Capture-MS Homo sapiens
6 PDGFRA 5156
Affinity Capture-MS Homo sapiens
7 SPX  
Affinity Capture-MS Homo sapiens
8 CEACAM8 1088
Affinity Capture-MS Homo sapiens
9 BMPR2 659
Affinity Capture-MS Homo sapiens
10 TRAV20  
Affinity Capture-MS Homo sapiens
11 C1QA 712
Affinity Capture-MS Homo sapiens
12 TMTC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SUOX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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