Gene description for GNA15
Gene name guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Gene symbol GNA15
Other names/aliases GNA16
Species Homo sapiens
 Database cross references - GNA15
ExoCarta ExoCarta_2769
Entrez Gene 2769
HGNC 4383
MIM 139314
UniProt P30679  
 GNA15 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for GNA15
Molecular Function
    G-protein beta/gamma-subunit complex binding GO:0031683 IBA
    metal ion binding GO:0046872 IEA
    signal transducer activity GO:0004871 IGI
    GTP binding GO:0005525 IEA
    G-protein coupled receptor binding GO:0001664 IBA
    GTPase activity GO:0003924 IEA
Biological Process
    phospholipase C-activating dopamine receptor signaling pathway GO:0060158 IBA
    adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188 IBA
    platelet activation GO:0030168 TAS
    metabolic process GO:0008152 TAS
    positive regulation of cytosolic calcium ion concentration GO:0007204 IGI
    activation of phospholipase C activity GO:0007202 TAS
    phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway GO:0007207 TAS
    blood coagulation GO:0007596 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    heterotrimeric G-protein complex GO:0005834 NAS
    cytosol GO:0005829 IGI
 Experiment description of studies that identified GNA15 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GNA15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADRBK1 156
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 LTB4R 1241
Invitro Homo sapiens
Invivo Homo sapiens
3 ADRB2  
Invivo Homo sapiens
4 IL8RA  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
5 F2R 2149
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
6 CNR1  
Invivo Homo sapiens
7 RGS2  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
8 CNR2  
Invivo Homo sapiens
9 TTC1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
10 IL8RB  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
11 CHRM2  
Invitro Homo sapiens
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