Gene description for AREG
Gene name amphiregulin
Gene symbol AREG
Other names/aliases AR
AREGB
CRDGF
SDGF
Species Homo sapiens
 Database cross references - AREG
ExoCarta ExoCarta_374
Entrez Gene 374
HGNC 651
MIM 104640
UniProt P15514  
 AREG identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
 Gene ontology annotations for AREG
Molecular Function
    epidermal growth factor receptor binding GO:0005154 IBA
    cytokine activity GO:0005125 IEA
    growth factor activity GO:0008083 IEA
    protein binding GO:0005515 IPI
Biological Process
    glial cell proliferation GO:0014009 IEA
    positive regulation of phosphorylation GO:0042327 IEA
    response to estradiol GO:0032355 IEA
    mammary gland branching involved in thelarche GO:0060744 IEA
    dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis GO:0060598 IEA
    cell-cell signaling GO:0007267 TAS
    positive regulation of cell proliferation GO:0008284 IBA
    response to peptide hormone GO:0043434 IEA
    response to glucocorticoid GO:0051384 IEA
    negative regulation of osteoblast differentiation GO:0045668 IEA
    G-protein coupled receptor signaling pathway GO:0007186 IDA
    mammary gland alveolus development GO:0060749 IEA
    response to cAMP GO:0051591 IEA
    neuron projection development GO:0031175 IEA
    cell proliferation GO:0008283 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 IDA
    epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA
    positive regulation of DNA replication GO:0045740 IMP
    response to hydrogen peroxide GO:0042542 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    extracellular space GO:0005615 IDA
    cytoplasm GO:0005737 IEA
    cell surface GO:0009986 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified AREG in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AREG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EGFR 1956
Reconstituted Complex Homo sapiens
2 CCND3  
Affinity Capture-MS Homo sapiens
3 MMP9 4318
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which AREG is involved
No pathways found





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