Gene description for Ncln
Gene name nicalin homolog (zebrafish)
Gene symbol Ncln
Other names/aliases 3100002P13Rik
AW120537
Species Mus musculus
 Database cross references - Ncln
ExoCarta ExoCarta_103425
Vesiclepedia VP_103425
Entrez Gene 103425
UniProt Q8VCM8  
 Ncln identified in sEVs derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Ncln
Molecular Function
    ribosome binding GO:0043022 ISO
    ribosome binding GO:0043022 ISS
Biological Process
    regulation of signal transduction GO:0009966 IBA
    regulation of signal transduction GO:0009966 IEA
    regulation of protein-containing complex assembly GO:0043254 IEA
    regulation of protein-containing complex assembly GO:0043254 ISO
    protein stabilization GO:0050821 IEA
    protein stabilization GO:0050821 ISO
    regulation of protein complex stability GO:0061635 IEA
    regulation of protein complex stability GO:0061635 ISO
    multi-pass transmembrane protein insertion into ER membrane GO:0160063 ISO
    multi-pass transmembrane protein insertion into ER membrane GO:0160063 ISS
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
    endoplasmic reticulum membrane GO:0005789 ISO
    protein-containing complex GO:0032991 ISO
    multi-pass translocon complex GO:0160064 ISO
    multi-pass translocon complex GO:0160064 ISS
 Experiment description of studies that identified Ncln in sEVs
1
Experiment ID 264
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors "Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ncln
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCNB1 891
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which Ncln is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here