Gene description for Samhd1
Gene name SAM domain and HD domain, 1
Gene symbol Samhd1
Other names/aliases E330031J07Rik
Mg11
Species Mus musculus
 Database cross references - Samhd1
ExoCarta ExoCarta_56045
Entrez Gene 56045
UniProt Q60710  
 Samhd1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Samhd1
Molecular Function
    nucleic acid binding GO:0003676 ISO
    catalytic activity GO:0003824 IEA
    metal ion binding GO:0046872 IEA
    dGTPase activity GO:0008832 ISO
    zinc ion binding GO:0008270 ISO
    RNA binding GO:0003723 ISO
    hydrolase activity GO:0016787 IEA
    dGTP binding GO:0032567 ISO
Biological Process
    protein homotetramerization GO:0051289 ISO
    dGTP catabolic process GO:0006203 ISO
    regulation of innate immune response GO:0045088 ISO
    dATP catabolic process GO:0046061 ISO
    immune system process GO:0002376 IEA
    metabolic process GO:0008152 IEA
    innate immune response GO:0045087 IEA
    defense response to virus GO:0051607 ISO
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    nucleus GO:0005634 ISO
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Samhd1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Samhd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Samhd1 is involved
No pathways found





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