Gene description for HS3ST3B1
Gene name heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
Gene symbol HS3ST3B1
Other names/aliases 3-OST-3B
3OST3B1
h3-OST-3B
Species Homo sapiens
 Database cross references - HS3ST3B1
ExoCarta ExoCarta_9953
Entrez Gene 9953
HGNC 5198
MIM 604058
UniProt Q9Y662  
 HS3ST3B1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for HS3ST3B1
Molecular Function
    [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity GO:0033872 IEA
    [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity GO:0008467 TAS
Biological Process
    heparan sulfate proteoglycan biosynthetic process, enzymatic modification GO:0015015 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    carbohydrate metabolic process GO:0005975 TAS
    heparan sulfate proteoglycan biosynthetic process GO:0015012 TAS
    glycosaminoglycan biosynthetic process GO:0006024 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified HS3ST3B1 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for HS3ST3B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HS3ST3B1 is involved
PathwayEvidenceSource
HS-GAG biosynthesis TAS Reactome





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