Gene description for HIPK1
Gene name homeodomain interacting protein kinase 1
Gene symbol HIPK1
Other names/aliases Myak
Nbak2
Species Homo sapiens
 Database cross references - HIPK1
ExoCarta ExoCarta_204851
Entrez Gene 204851
HGNC 19006
MIM 608003
UniProt Q86Z02  
 HIPK1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for HIPK1
Molecular Function
    protein binding GO:0005515 IPI
    protein serine/threonine kinase activity GO:0004674 IEA
    ATP binding GO:0005524 IEA
Biological Process
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IEA
    lens induction in camera-type eye GO:0060235 IEA
    positive regulation of cell proliferation GO:0008284 IEA
    definitive hemopoiesis GO:0060216 ISS
    regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 IDA
    eye development GO:0001654 ISS
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    endothelial cell apoptotic process GO:0072577 IDA
    retina layer formation GO:0010842 IEA
    neuron differentiation GO:0030182 IEA
    embryonic camera-type eye morphogenesis GO:0048596 IEA
    positive regulation of angiogenesis GO:0045766 ISS
    protein phosphorylation GO:0006468 IEA
    embryonic retina morphogenesis in camera-type eye GO:0060059 IEA
    iris morphogenesis GO:0061072 IEA
    smoothened signaling pathway GO:0007224 IEA
    anterior/posterior pattern specification GO:0009952 IEA
    extrinsic apoptotic signaling pathway GO:0097191 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nuclear speck GO:0016607 IEA
    nucleus GO:0005634 IDA
    PML body GO:0016605 IEA
 Experiment description of studies that identified HIPK1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for HIPK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DAXX  
Invitro Homo sapiens
Invivo Homo sapiens
2 PRPF40A 55660
Affinity Capture-MS Homo sapiens
3 TP53  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
4 NKX2-5  
Affinity Capture-MS Homo sapiens
5 SNIP1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HIPK1 is involved
PathwayEvidenceSource
YAP1- and WWTR1 (TAZ)-stimulated gene expression TAS Reactome





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