Gene description for ADCY2
Gene name adenylate cyclase 2 (brain)
Gene symbol ADCY2
Other names/aliases AC2
HBAC2
Species Homo sapiens
 Database cross references - ADCY2
ExoCarta ExoCarta_108
Entrez Gene 108
HGNC 233
MIM 103071
UniProt Q08462  
 ADCY2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ADCY2
Molecular Function
    G-protein beta/gamma-subunit complex binding GO:0031683 IEA
    adenylate cyclase activity GO:0004016 NAS
    adenylate cyclase binding GO:0008179 ISS
    protein heterodimerization activity GO:0046982 ISS
    metal ion binding GO:0046872 IEA
    ATP binding GO:0005524 IEA
    calcium- and calmodulin-responsive adenylate cyclase activity GO:0008294 IEA
Biological Process
    adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188 ISS
    adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 TAS
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 TAS
    transmembrane transport GO:0055085 TAS
    cAMP biosynthetic process GO:0006171 ISS
    synaptic transmission GO:0007268 TAS
    small molecule metabolic process GO:0044281 TAS
    cellular response to glucagon stimulus GO:0071377 TAS
    activation of protein kinase A activity GO:0034199 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    water transport GO:0006833 TAS
    innate immune response GO:0045087 TAS
    energy reserve metabolic process GO:0006112 TAS
    activation of phospholipase C activity GO:0007202 TAS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    intracellular signal transduction GO:0035556 IEA
    signal transduction GO:0007165 TAS
    renal water homeostasis GO:0003091 TAS
Subcellular Localization
    intracellular GO:0005622 ISS
    membrane GO:0016020 ISS
    plasma membrane GO:0005886 TAS
    cytoplasm GO:0005737 IDA
    integral component of membrane GO:0016021 IEA
    protein complex GO:0043234 IEA
    dendrite GO:0030425 ISS
    membrane raft GO:0045121 ISS
 Experiment description of studies that identified ADCY2 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ADCY2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADCY1 107
Invitro Homo sapiens
2 ADCY5  
Invitro Homo sapiens
3 GNAS 2778
Invitro Homo sapiens
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