Gene description for NINJ1
Gene name ninjurin 1
Gene symbol NINJ1
Other names/aliases NIN1
NINJURIN
Species Homo sapiens
 Database cross references - NINJ1
ExoCarta ExoCarta_4814
Vesiclepedia VP_4814
Entrez Gene 4814
HGNC 7824
MIM 602062
UniProt Q92982  
 NINJ1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for NINJ1
Molecular Function
    lipopolysaccharide binding GO:0001530 IDA
    protein binding GO:0005515 IPI
    cell adhesion mediator activity GO:0098631 IDA
    membrane destabilizing activity GO:0140912 IDA
Biological Process
    angiogenesis GO:0001525 IEA
    leukocyte chemotaxis involved in inflammatory response GO:0002232 IDA
    inflammatory response GO:0006954 IDA
    cell adhesion GO:0007155 IBA
    cell adhesion GO:0007155 IDA
    nervous system development GO:0007399 TAS
    cytolysis GO:0019835 IDA
    killing of cells of another organism GO:0031640 IEA
    heterotypic cell-cell adhesion GO:0034113 ISS
    positive regulation of toll-like receptor 4 signaling pathway GO:0034145 ISS
    tissue regeneration GO:0042246 IEA
    muscle cell differentiation GO:0042692 ISS
    positive regulation of angiogenesis GO:0045766 IDA
    positive regulation of inflammatory response GO:0050729 IDA
    protein homooligomerization GO:0051260 IDA
    cellular hyperosmotic response GO:0071474 ISS
    regulation of monocyte chemotaxis GO:0090025 IDA
    programmed necrotic cell death GO:0097300 IDA
    ferroptosis GO:0097707 ISS
    pyroptotic cell death GO:0141201 IDA
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IDA
    synaptic membrane GO:0097060 IEA
 Experiment description of studies that identified NINJ1 in exosomes
1
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for NINJ1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SGCB 6443
Two-hybrid Homo sapiens
2 TMEM31  
Two-hybrid Homo sapiens
3 KRT40  
Two-hybrid Homo sapiens
4 CEACAM3  
Two-hybrid Homo sapiens
5 MUC1 4582
Two-hybrid Homo sapiens
6 LIME1 54923
Two-hybrid Homo sapiens
7 FCGR1A  
Two-hybrid Homo sapiens
8 GPX8 493869
Two-hybrid Homo sapiens
9 GOLM1 51280
Two-hybrid Homo sapiens
10 CD200R1 131450
Two-hybrid Homo sapiens
11 TMEM14B  
Two-hybrid Homo sapiens
12 TIMMDC1  
Two-hybrid Homo sapiens
13 EBP  
Two-hybrid Homo sapiens
14 TMEM56  
Two-hybrid Homo sapiens
15 FNDC9  
Two-hybrid Homo sapiens
16 HIVEP1 3096
Two-hybrid Homo sapiens
17 CREB3L1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which NINJ1 is involved
No pathways found





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