Gene description for KLKB1
Gene name kallikrein B, plasma (Fletcher factor) 1
Gene symbol KLKB1
Other names/aliases KLK3
PPK
Species Homo sapiens
 Database cross references - KLKB1
ExoCarta ExoCarta_3818
Entrez Gene 3818
HGNC 6371
MIM 229000
UniProt P03952  
 KLKB1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for KLKB1
Molecular Function
    serine-type endopeptidase activity GO:0004252 IEA
    protein binding GO:0005515 IPI
Biological Process
    proteolysis GO:0006508 TAS
    blood coagulation GO:0007596 TAS
    blood coagulation, intrinsic pathway GO:0007597 TAS
    Factor XII activation GO:0002542 TAS
    zymogen activation GO:0031638 TAS
    extracellular matrix disassembly GO:0022617 TAS
    plasminogen activation GO:0031639 IDA
    positive regulation of fibrinolysis GO:0051919 IDA
    fibrinolysis GO:0042730 IEA
    extracellular matrix organization GO:0030198 TAS
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified KLKB1 in exosomes
1
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for KLKB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SERPINA5 5104
Reconstituted Complex Homo sapiens
2 KNG1 3827
Invitro Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which KLKB1 is involved
PathwayEvidenceSource
Activation of Matrix Metalloproteinases TAS Reactome
Intrinsic Pathway of Fibrin Clot Formation TAS Reactome





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