Gene description for ATP5G3
Gene name ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
Gene symbol ATP5G3
Other names/aliases P3
Species Homo sapiens
 Database cross references - ATP5G3
ExoCarta ExoCarta_518
Entrez Gene 518
HGNC 843
MIM 602736
UniProt P48201  
 ATP5G3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ATP5G3
Molecular Function
    hydrogen ion transmembrane transporter activity GO:0015078 IEA
    lipid binding GO:0008289 IEA
    transporter activity GO:0005215 NAS
Biological Process
    small molecule metabolic process GO:0044281 TAS
    ATP hydrolysis coupled proton transport GO:0015991 IEA
    respiratory electron transport chain GO:0022904 TAS
    mitochondrial ATP synthesis coupled proton transport GO:0042776 TAS
    cellular metabolic process GO:0044237 TAS
Subcellular Localization
    mitochondrial outer membrane GO:0005741 TAS
    proton-transporting ATP synthase complex, coupling factor F(o) GO:0045263 IEA
    integral component of membrane GO:0016021 IEA
    mitochondrial proton-transporting ATP synthase complex GO:0005753 TAS
 Experiment description of studies that identified ATP5G3 in exosomes
1
Experiment ID 236
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ATP5G3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ABHD16A 7920
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ATP5G3 is involved
PathwayEvidenceSource
Formation of ATP by chemiosmotic coupling TAS Reactome





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