Gene description for ATP5G3
Gene name ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
Gene symbol ATP5G3
Other names/aliases P3
Species Homo sapiens
 Database cross references - ATP5G3
ExoCarta ExoCarta_518
Vesiclepedia VP_518
Entrez Gene 518
HGNC 843
MIM 602736
UniProt P48201  
 ATP5G3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ATP5G3
Molecular Function
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
    proton transmembrane transporter activity GO:0015078 IEA
Biological Process
    proton motive force-driven ATP synthesis GO:0015986 IBA
    proton motive force-driven ATP synthesis GO:0015986 NAS
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    proton-transporting ATP synthase complex, coupling factor F(o) GO:0045263 IBA
 Experiment description of studies that identified ATP5G3 in exosomes
1
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ATP5G3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GOLGA4  
Affinity Capture-MS Homo sapiens
2 NXF1 10482
Affinity Capture-RNA Homo sapiens
3 VKORC1 79001
Two-hybrid Homo sapiens
4 KRAS 3845
Negative Genetic Homo sapiens
5 ABHD16A 7920
Two-hybrid Homo sapiens
6 TMEM31  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
7 ATP5D 513
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 C4orf32  
Affinity Capture-MS Homo sapiens
9 DGCR2 9993
Affinity Capture-MS Homo sapiens
10 MOV10 4343
Affinity Capture-RNA Homo sapiens
11 MTNR1A  
Two-hybrid Homo sapiens
12 GHDC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ATPIF1 93974
Affinity Capture-MS Homo sapiens
14 ATP5B 506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 DDX58 23586
Affinity Capture-RNA Homo sapiens
16 COL20A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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