Gene description for SLC46A1
Gene name solute carrier family 46 (folate transporter), member 1
Gene symbol SLC46A1
Other names/aliases G21
HCP1
PCFT
Species Homo sapiens
 Database cross references - SLC46A1
ExoCarta ExoCarta_113235
Entrez Gene 113235
HGNC 30521
MIM 611672
UniProt Q96NT5  
 SLC46A1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC46A1
Molecular Function
    folic acid binding GO:0005542 IEA
    heme transporter activity GO:0015232 IEA
    folic acid transporter activity GO:0008517 IDA
    methotrexate transporter activity GO:0015350 IEA
Biological Process
    heme transport GO:0015886 IEA
    methotrexate transport GO:0051958 IEA
    folic acid metabolic process GO:0046655 TAS
    cellular iron ion homeostasis GO:0006879 TAS
    vitamin metabolic process GO:0006766 TAS
    water-soluble vitamin metabolic process GO:0006767 TAS
    transmembrane transport GO:0055085 TAS
    folic acid transport GO:0015884 IDA
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    cytoplasm GO:0005737 ISS
    brush border membrane GO:0031526 IEA
    apical plasma membrane GO:0016324 IDA
    plasma membrane GO:0005886 TAS
    integral component of membrane GO:0016021 IEA
    cell surface GO:0009986 IDA
 Experiment description of studies that identified SLC46A1 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC46A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC46A1 is involved
PathwayEvidenceSource
Iron uptake and transport TAS Reactome
Metabolism of folate and pterines TAS Reactome





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