Gene description for HSD17B2
Gene name hydroxysteroid (17-beta) dehydrogenase 2
Gene symbol HSD17B2
Other names/aliases EDH17B2
HSD17
SDR9C2
Species Homo sapiens
 Database cross references - HSD17B2
ExoCarta ExoCarta_3294
Vesiclepedia VP_3294
Entrez Gene 3294
HGNC 5211
MIM 109685
UniProt P37059  
 HSD17B2 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for HSD17B2
Molecular Function
    testosterone dehydrogenase (NAD+) activity GO:0047035 IDA
    17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity GO:0047006 TAS
    estradiol 17-beta-dehydrogenase activity GO:0004303 IDA
Biological Process
    placenta development GO:0001890 IEA
    response to retinoic acid GO:0032526 IDA
    oxidation-reduction process GO:0055114 IEA
    steroid biosynthetic process GO:0006694 IEA
    in utero embryonic development GO:0001701 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified HSD17B2 in exosomes
1
Experiment ID 834
MISEV standards
EM
EV Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
EV Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for HSD17B2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HSD17B2 is involved
No pathways found





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