Gene description for FXYD2
Gene name FXYD domain containing ion transport regulator 2
Gene symbol FXYD2
Other names/aliases ATP1G1
HOMG2
Species Homo sapiens
 Database cross references - FXYD2
ExoCarta ExoCarta_486
Entrez Gene 486
HGNC 4026
MIM 601814
UniProt P54710  
 FXYD2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for FXYD2
Molecular Function
    sodium:potassium-exchanging ATPase activity GO:0005391 IEA
    transporter activity GO:0005215 TAS
    ion channel activity GO:0005216 IEA
    sodium channel regulator activity GO:0017080 IBA
Biological Process
    transport GO:0006810 TAS
    transmembrane transport GO:0055085 TAS
    sodium ion export from cell GO:0036376 ISS
    regulation of sodium ion transmembrane transporter activity GO:2000649 IBA
    potassium ion import across plasma membrane GO:1990573 ISS
    regulation of cell growth GO:0001558 IEA
    regulation of cell proliferation GO:0042127 IEA
    ion transmembrane transport GO:0034220 TAS
Subcellular Localization
    sodium:potassium-exchanging ATPase complex GO:0005890 IEA
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
    basolateral plasma membrane GO:0016323 IEA
    intracellular membrane-bounded organelle GO:0043231 IEA
    integral component of plasma membrane GO:0005887 IBA
 Experiment description of studies that identified FXYD2 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 13
ISEV standards
✔
IEM
EV Biophysical techniques
✔
Alix|RAB4|RAB5B|RAB11|TSG101
EV Cytosolic markers
✔
CD9|AQP2|AQP1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors Pisitkun T, Shen RF, Knepper MA
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
3
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FXYD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FXYD2 is involved
PathwayEvidenceSource
Ion transport by P-type ATPases TAS Reactome





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