Gene description for PRG4
Gene name proteoglycan 4
Gene symbol PRG4
Other names/aliases CACP
HAPO
JCAP
MSF
SZP
Species Homo sapiens
 Database cross references - PRG4
ExoCarta ExoCarta_10216
Entrez Gene 10216
HGNC 9364
MIM 604283
UniProt Q92954  
 PRG4 identified in exosomes derived from the following tissue/cell type
Plasma 19028452    
 Gene ontology annotations for PRG4
Molecular Function
    polysaccharide binding GO:0030247 IEA
    scavenger receptor activity GO:0005044 IEA
Biological Process
    cell proliferation GO:0008283 TAS
    negative regulation of interleukin-6 biosynthetic process GO:0045409 IEA
    hematopoietic stem cell proliferation GO:0071425 IEA
    regulation of cell proliferation GO:0042127 IEA
    immune response GO:0006955 IEA
    receptor-mediated endocytosis GO:0006898 IEA
Subcellular Localization
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified PRG4 in exosomes
1
Experiment ID 44
ISEV standards
IEM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for PRG4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PRG4 is involved
No pathways found





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