Gene description for CNTFR
Gene name ciliary neurotrophic factor receptor
Gene symbol CNTFR
Other names/aliases -
Species Homo sapiens
 Database cross references - CNTFR
ExoCarta ExoCarta_1271
Entrez Gene 1271
HGNC 2170
MIM 118946
UniProt P26992  
 CNTFR identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for CNTFR
Molecular Function
    ciliary neurotrophic factor receptor activity GO:0004897 IDA
    cytokine binding GO:0019955 IPI
    receptor binding GO:0005102 IPI
Biological Process
    ciliary neurotrophic factor-mediated signaling pathway GO:0070120 IDA
    positive regulation of cell proliferation GO:0008284 IEA
    nervous system development GO:0007399 TAS
    skeletal muscle organ development GO:0060538 IEA
    suckling behavior GO:0001967 IEA
    sex differentiation GO:0007548 IEA
    signal transduction GO:0007165 NAS
    brainstem development GO:0003360 IEA
    negative regulation of neuron apoptotic process GO:0043524 IEA
Subcellular Localization
    apical plasma membrane GO:0016324 IDA
    extrinsic component of membrane GO:0019898 TAS
    CNTFR-CLCF1 complex GO:0097059 IDA
    ciliary neurotrophic factor receptor complex GO:0070110 IDA
    anchored component of membrane GO:0031225 IEA
 Experiment description of studies that identified CNTFR in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CNTFR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CRLF1  
Invivo Homo sapiens
Invitro Homo sapiens
2 CNTF  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
3 APPBP2  
Two-hybrid Homo sapiens
4 IL6ST 3572
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 KRTAP4-12  
Two-hybrid Homo sapiens
6 PLSCR1 5359
Two-hybrid Homo sapiens
7 LIFR 3977
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
8 CLCF1  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
View the network image/svg+xml
 Pathways in which CNTFR is involved
No pathways found

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