Gene description for OSM
Gene name oncostatin M
Gene symbol OSM
Other names/aliases -
Species Homo sapiens
 Database cross references - OSM
ExoCarta ExoCarta_5008
Entrez Gene 5008
HGNC 8506
MIM 165095
UniProt P13725  
 OSM identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for OSM
Molecular Function
    oncostatin-M receptor binding GO:0005147 IPI
    cytokine activity GO:0005125 IDA
    growth factor activity GO:0008083 IDA
Biological Process
    negative regulation of hormone secretion GO:0046888 IDA
    negative regulation of meiotic nuclear division GO:0045835 IEA
    tyrosine phosphorylation of Stat3 protein GO:0042503 IEA
    peripheral nervous system development GO:0007422 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    positive regulation of MAPK cascade GO:0043410 IDA
    positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 IDA
    cell proliferation GO:0008283 TAS
    oncostatin-M-mediated signaling pathway GO:0038165 IDA
    response to heat GO:0009408 IEA
    positive regulation of acute inflammatory response GO:0002675 IC
    negative regulation of cell proliferation GO:0008285 TAS
    immune response GO:0006955 IEA
    positive regulation of cell division GO:0051781 IEA
    positive regulation of apoptotic signaling pathway GO:2001235 IEA
    positive regulation of cell proliferation GO:0008284 IDA
    multicellular organismal development GO:0007275 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    behavioral response to pain GO:0048266 IEA
    regulation of growth GO:0040008 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA
    tyrosine phosphorylation of Stat5 protein GO:0042506 IEA
    tyrosine phosphorylation of Stat1 protein GO:0042508 IEA
Subcellular Localization
    extracellular space GO:0005615 IEA
    intracellular GO:0005622 IEA
 Experiment description of studies that identified OSM in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for OSM
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OSMR 9180
Invitro Homo sapiens
Invivo Homo sapiens
2 IL6ST 3572
Invivo Homo sapiens
3 COL4A5  
Invitro Homo sapiens
4 COL4A2 1284
Invitro Homo sapiens
5 COL4A1 1282
Invitro Homo sapiens
6 COL4A4  
Invitro Homo sapiens
7 COL4A3 1285
Invitro Homo sapiens
8 LIFR 3977
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
9 COL4A6  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which OSM is involved
No pathways found

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