Gene description for LIF
Gene name leukemia inhibitory factor
Gene symbol LIF
Other names/aliases CDF
Species Homo sapiens
 Database cross references - LIF
ExoCarta ExoCarta_3976
Entrez Gene 3976
HGNC 6596
MIM 159540
UniProt P15018  
 LIF identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for LIF
Molecular Function
    cytokine activity GO:0005125 IDA
    RNA polymerase II transcription factor recruiting transcription factor activity GO:0001135 IDA
    leukemia inhibitory factor receptor binding GO:0005146 IPI
    growth factor activity GO:0008083 IDA
    receptor binding GO:0005102 IPI
Biological Process
    regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 IDA
    positive regulation of astrocyte differentiation GO:0048711 IEA
    positive regulation of MAPK cascade GO:0043410 IDA
    leukemia inhibitory factor signaling pathway GO:0048861 IDA
    spongiotrophoblast differentiation GO:0060708 IEA
    stem cell maintenance GO:0019827 IEA
    muscle organ morphogenesis GO:0048644 IEA
    positive regulation of macrophage differentiation GO:0045651 IDA
    positive regulation of protein localization to nucleus GO:1900182 IDA
    trophoblast giant cell differentiation GO:0060707 IEA
    blood vessel remodeling GO:0001974 IEA
    lung alveolus development GO:0048286 IEA
    lung lobe morphogenesis GO:0060463 IEA
    tyrosine phosphorylation of Stat3 protein GO:0042503 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA
    positive regulation of histone H3-K27 acetylation GO:1901676 IDA
    positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 IDA
    positive regulation of cell proliferation GO:0008284 IDA
    transcription from RNA polymerase II promoter GO:0006366 IDA
    positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 IDA
    positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 IDA
    immune response GO:0006955 IEA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA
    decidualization GO:0046697 IEA
    negative regulation of cell proliferation GO:0008285 IEA
    negative regulation of hormone secretion GO:0046888 IDA
    embryo implantation GO:0007566 IEA
    positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    lung vasculature development GO:0060426 IEA
    multicellular organismal development GO:0007275 TAS
    neuron development GO:0048666 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    negative regulation of meiotic nuclear division GO:0045835 IEA
Subcellular Localization
    extracellular space GO:0005615 IC
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified LIF in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for LIF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LIFR 3977
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which LIF is involved
No pathways found

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