Gene description for LIF
Gene name	leukemia inhibitory factor
Gene symbol	LIF
Other names/aliases	CDF DIA HILDA MLPLI
Species	Homo sapiens
Database cross references - LIF
ExoCarta	ExoCarta_3976
Vesiclepedia	VP_3976
Entrez Gene	3976
HGNC	6596
MIM	159540
UniProt	P15018
LIF identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for LIF

Molecular Function     signaling receptor binding GO:0005102 IPI     cytokine activity GO:0005125 IBA     cytokine activity GO:0005125 IDA     leukemia inhibitory factor receptor binding GO:0005146 IBA     leukemia inhibitory factor receptor binding GO:0005146 IDA     leukemia inhibitory factor receptor binding GO:0005146 IPI     protein binding GO:0005515 IPI     growth factor activity GO:0008083 IBA     growth factor activity GO:0008083 IDA Biological Process     cell morphogenesis GO:0000902 IEA     response to hypoxia GO:0001666 IEA     blood vessel remodeling GO:0001974 IEA     immune response GO:0006955 IEA     embryo implantation GO:0007566 IEA     positive regulation of cell population proliferation GO:0008284 IBA     positive regulation of cell population proliferation GO:0008284 IDA     positive regulation of cell population proliferation GO:0008284 IDA     negative regulation of cell population proliferation GO:0008285 IEA     gene expression GO:0010467 IEA     positive regulation of gene expression GO:0010628 IEA     macrophage differentiation GO:0030225 TAS     positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA     positive regulation of cell adhesion mediated by integrin GO:0033630 IMP     somatic stem cell population maintenance GO:0035019 IEA     positive regulation of MAPK cascade GO:0043410 IDA     regulation of cell differentiation GO:0045595 IBA     positive regulation of macrophage differentiation GO:0045651 IDA     negative regulation of meiotic nuclear division GO:0045835 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     decidualization GO:0046697 IEA     negative regulation of hormone secretion GO:0046888 IDA     fibroblast proliferation GO:0048144 IEA     positive regulation of fibroblast proliferation GO:0048146 IEA     lung alveolus development GO:0048286 IEA     muscle organ morphogenesis GO:0048644 IEA     neuron development GO:0048666 IEA     positive regulation of astrocyte differentiation GO:0048711 IEA     leukemia inhibitory factor signaling pathway GO:0048861 IBA     leukemia inhibitory factor signaling pathway GO:0048861 IDA     stem cell differentiation GO:0048863 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     lung vasculature development GO:0060426 IEA     lung lobe morphogenesis GO:0060463 IEA     trophoblast giant cell differentiation GO:0060707 IEA     negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA     positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 IDA     regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 IDA     cell surface receptor signaling pathway via STAT GO:0097696 IDA     meiotic nuclear division GO:0140013 IEA     positive regulation of receptor signaling pathway via STAT GO:1904894 IDA Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IC     cytosol GO:0005829 IDA