Gene description for SFRP1
Gene name	secreted frizzled-related protein 1
Gene symbol	SFRP1
Other names/aliases	FRP FRP-1 FRP1 FrzA SARP2
Species	Homo sapiens
Database cross references - SFRP1
ExoCarta	ExoCarta_6422
Entrez Gene	6422
HGNC	10776
MIM	604156
UniProt	Q8N474
SFRP1 identified in exosomes derived from the following tissue/cell type
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Mesenchymal stem cells	Unpublished / Not applicable
Saliva	19199708

Gene ontology annotations for SFRP1

Molecular Function     Wnt-activated receptor activity GO:0042813 IBA     frizzled binding GO:0005109 IPI     drug binding GO:0008144 IDA     Wnt-protein binding GO:0017147 IPI     protein binding GO:0005515 IPI     G-protein coupled receptor activity GO:0004930 IBA     identical protein binding GO:0042802 IPI     cysteine-type endopeptidase activity GO:0004197 IMP     heparin binding GO:0008201 IDA Biological Process     regulation of angiogenesis GO:0045765 ISS     negative regulation of fibroblast apoptotic process GO:2000270 IDA     negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification GO:2000054 IDA     hematopoietic progenitor cell differentiation GO:0002244 IDA     cellular response to X-ray GO:0071481 IEA     positive regulation of epithelial cell proliferation GO:0050679 IMP     cellular response to tumor necrosis factor GO:0071356 IDA     negative regulation of transcription, DNA-templated GO:0045892 IMP     positive regulation of canonical Wnt signaling pathway GO:0090263 IDA     hematopoietic stem cell differentiation GO:0060218 IDA     negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation GO:2000080 IDA     ureteric bud development GO:0001657 IEA     negative regulation of fibroblast proliferation GO:0048147 IDA     Wnt signaling pathway involved in somitogenesis GO:0090244 IEA     positive regulation of apoptotic process GO:0043065 IMP     cellular response to prostaglandin E stimulus GO:0071380 IEP     cellular response to heparin GO:0071504 IDA     cellular response to estradiol stimulus GO:0071392 IEP     convergent extension involved in somitogenesis GO:0090246 IEA     positive regulation of smoothened signaling pathway GO:0045880 IMP     positive regulation of non-canonical Wnt signaling pathway GO:2000052 IDA     negative regulation of epithelial cell proliferation GO:0050680 IDA     negative regulation of epithelial to mesenchymal transition GO:0010719 IDA     prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 IEA     positive regulation of stress fiber assembly GO:0051496 ISS     cellular response to BMP stimulus GO:0071773 IEP     negative regulation of cell proliferation GO:0008285 IDA     cellular response to interleukin-1 GO:0071347 IEP     cellular response to transforming growth factor beta stimulus GO:0071560 IEP     dorsal/ventral axis specification GO:0009950 IDA     response to drug GO:0042493 IDA     positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 IDA     negative regulation of gene expression GO:0010629 IDA     bone trabecula formation GO:0060346 IEA     negative regulation of apoptotic process GO:0043066 IMP     positive regulation of fat cell differentiation GO:0045600 IDA     positive regulation of fibroblast apoptotic process GO:2000271 IDA     cellular response to estrogen stimulus GO:0071391 IDA     negative regulation of planar cell polarity pathway involved in axis elongation GO:2000041 IEA     positive regulation of focal adhesion assembly GO:0051894 ISS     osteoblast differentiation GO:0001649 IEP     negative regulation of insulin secretion GO:0046676 IDA     cellular response to hypoxia GO:0071456 IEP     regulation of cell cycle process GO:0010564 IMP     canonical Wnt signaling pathway GO:0060070 IDA     cellular response to fibroblast growth factor stimulus GO:0044344 IDA     positive regulation of GTPase activity GO:0043547 ISS     negative regulation of osteoblast differentiation GO:0045668 IEA     negative regulation of Wnt signaling pathway GO:0030178 IMP     menstrual cycle phase GO:0022601 IEP     negative regulation of JUN kinase activity GO:0043508 IEA     cellular response to vitamin D GO:0071305 IEP     negative regulation of cell migration GO:0030336 IDA     negative regulation of B cell differentiation GO:0045578 IMP     response to organic cyclic compound GO:0014070 IDA     digestive tract morphogenesis GO:0048546 IEA     negative regulation of cell growth GO:0030308 IDA     positive regulation of transcription, DNA-templated GO:0045893 IMP     regulation of branching involved in prostate gland morphogenesis GO:0060687 IEA     negative regulation of androgen receptor signaling pathway GO:0060766 IDA     negative regulation of canonical Wnt signaling pathway GO:0090090 TAS     male gonad development GO:0008584 IEA     female gonad development GO:0008585 IEA     negative regulation of BMP signaling pathway GO:0030514 IEA     negative regulation of osteoblast proliferation GO:0033689 IMP     positive regulation of cell-matrix adhesion GO:0001954 ISS     planar cell polarity pathway involved in neural tube closure GO:0090179 IEA     neural crest cell fate commitment GO:0014034 IEA     cellular response to starvation GO:0009267 IEP     non-canonical Wnt signaling pathway GO:0035567 IBA     stromal-epithelial cell signaling involved in prostate gland development GO:0044345 IEA     positive regulation of Wnt signaling pathway GO:0030177 IDA     negative regulation of ossification GO:0030279 IMP     positive regulation of cell proliferation GO:0008284 IDA     somatic stem cell maintenance GO:0035019 IEA     negative regulation of osteoclast differentiation GO:0045671 IEA     negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 IDA     negative regulation of bone remodeling GO:0046851 IMP     proteolysis GO:0006508 IMP     positive regulation of cell growth GO:0030307 IDA     cellular response to growth factor stimulus GO:0071363 IDA Subcellular Localization     extracellular space GO:0005615 IDA     cytosol GO:0005829 IDA     extracellular region GO:0005576 TAS     plasma membrane GO:0005886 ISS     extracellular matrix GO:0031012 IDA     cell surface GO:0009986 IDA     extracellular exosome GO:0070062 IDA     integral component of membrane GO:0016021 IBA     proteinaceous extracellular matrix GO:0005578 IDA     intracellular GO:0005622 IDA