Gene description for UNC80
Gene name unc-80 homolog (C. elegans)
Gene symbol UNC80
Other names/aliases C2orf21
UNC-80
Species Homo sapiens
 Database cross references - UNC80
ExoCarta ExoCarta_285175
Entrez Gene 285175
HGNC 26582
MIM 612636
UniProt Q8N2C7  
 UNC80 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for UNC80
Biological Process
    ion transmembrane transport GO:0034220 TAS
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified UNC80 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for UNC80
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which UNC80 is involved
PathwayEvidenceSource
Stimuli-sensing channels TAS Reactome





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