Gene description for AOX1
Gene name aldehyde oxidase 1
Gene symbol AOX1
Other names/aliases AO
AOH1
Species Homo sapiens
 Database cross references - AOX1
ExoCarta ExoCarta_316
Entrez Gene 316
HGNC 553
MIM 602841
UniProt Q06278  
 AOX1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for AOX1
Molecular Function
    flavin adenine dinucleotide binding GO:0050660 IEA
    electron carrier activity GO:0009055 IEA
    2 iron, 2 sulfur cluster binding GO:0051537 IEA
    UDP-N-acetylmuramate dehydrogenase activity GO:0008762 IEA
    molybdopterin cofactor binding GO:0043546 IEA
    xanthine dehydrogenase activity GO:0004854 TAS
    aldehyde oxidase activity GO:0004031 TAS
    iron ion binding GO:0005506 IEA
    NAD binding GO:0051287 IEA
Biological Process
    vitamin metabolic process GO:0006766 TAS
    vitamin B6 metabolic process GO:0042816 TAS
    reactive oxygen species metabolic process GO:0072593 TAS
    inflammatory response GO:0006954 TAS
    oxidation-reduction process GO:0055114 IEA
    small molecule metabolic process GO:0044281 TAS
    water-soluble vitamin metabolic process GO:0006767 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified AOX1 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for AOX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which AOX1 is involved
PathwayEvidenceSource
Vitamins B6 activation to pyridoxal phosphate TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here