Gene description for PLA2G6
Gene name phospholipase A2, group VI (cytosolic, calcium-independent)
Gene symbol PLA2G6
Other names/aliases CaI-PLA2
GVI
INAD1
IPLA2-VIA
NBIA2
NBIA2A
NBIA2B
PARK14
PLA2
PNPLA9
iPLA2
iPLA2beta
Species Homo sapiens
 Database cross references - PLA2G6
ExoCarta ExoCarta_8398
Vesiclepedia VP_8398
Entrez Gene 8398
HGNC 9039
MIM 603604
UniProt O60733  
 PLA2G6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PLA2G6
Molecular Function
    calmodulin binding GO:0005516 IEA
    ATP-dependent protein binding GO:0043008 IEA
    calcium-independent phospholipase A2 activity GO:0047499 IEA
    phospholipase A2 activity GO:0004623 TAS
Biological Process
    urinary bladder smooth muscle contraction GO:0014832 IEA
    positive regulation of release of cytochrome c from mitochondria GO:0090200 IEA
    cardiolipin acyl-chain remodeling GO:0035965 TAS
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IEA
    positive regulation of vasodilation GO:0045909 IEA
    cardiolipin biosynthetic process GO:0032049 IMP
    chemotaxis GO:0006935 IEA
    positive regulation of protein kinase C signaling GO:0090037 IEA
    positive regulation of ceramide biosynthetic process GO:2000304 IEA
    lipid catabolic process GO:0016042 IEA
    regulation of store-operated calcium channel activity GO:1901339 IEA
    positive regulation of exocytosis GO:0045921 IEA
    phosphatidylcholine acyl-chain remodeling GO:0036151 TAS
    phospholipid metabolic process GO:0006644 TAS
    glycerophospholipid biosynthetic process GO:0046474 TAS
    positive regulation of arachidonic acid secretion GO:0090238 IEA
    memory GO:0007613 IEA
    small molecule metabolic process GO:0044281 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    response to endoplasmic reticulum stress GO:0034976 IEA
    innate immune response GO:0045087 TAS
    positive regulation of cytosolic calcium ion concentration GO:0007204 IEA
    phosphatidylethanolamine acyl-chain remodeling GO:0036152 TAS
    maternal process involved in female pregnancy GO:0060135 IEA
    positive regulation of protein phosphorylation GO:0001934 IEA
    negative regulation of synaptic transmission, glutamatergic GO:0051967 IEA
Subcellular Localization
    mitochondrion GO:0005739 IEA
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IEA
    microtubule organizing center GO:0005815 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PLA2G6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PLA2G6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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