Gene description for GRIP2
Gene name glutamate receptor interacting protein 2
Gene symbol GRIP2
Other names/aliases -
Species Homo sapiens
 Database cross references - GRIP2
ExoCarta ExoCarta_80852
Vesiclepedia VP_80852
Entrez Gene 80852
HGNC 23841
UniProt Q9C0E4  
 GRIP2 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for GRIP2
Molecular Function
    glutamate receptor binding GO:0035254 IEA
Biological Process
    Notch signaling pathway GO:0007219 IEA
    artery smooth muscle contraction GO:0014824 IEA
    positive regulation of blood pressure GO:0045777 IEA
    neurotransmitter receptor transport, endosome to postsynaptic membrane GO:0098887 IBA
    vesicle-mediated transport in synapse GO:0099003 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
    neuron spine GO:0044309 IEA
    postsynaptic membrane GO:0045211 IEA
    glutamatergic synapse GO:0098978 IEA
    postsynaptic density, intracellular component GO:0099092 IEA
 Experiment description of studies that identified GRIP2 in sEVs
1
Experiment ID 193
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GRIP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GFI1B  
Two-hybrid Homo sapiens
2 ERC2 26059
Affinity Capture-Western Homo sapiens
3 CSPG4 1464
Two-hybrid Homo sapiens
4 GIT1 28964
Affinity Capture-Western Homo sapiens
5 PPFIA1 8500
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 TRIM21 6737
Affinity Capture-MS Homo sapiens
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